75735-47-6

Upstream product

• 67-56-1 methanol 
• 36034-99-8 4-methyl-5-nitrothiophene-2-carboxylic acid 
• 14282-78-1 4-methylthiophene-2-carboxylic acid 
• 6317-37-9 5-nitrothiophene-2-carboxylic acid 
• 4521-33-9 5-nitro-2-thiophenecarboxaldehyde 
• 5380-42-7 thiophene-2-carboxylic acid methyl ester 
• 5832-01-9 methyl 5-nitrothiophene-2-carboxylate 
• 64-19-7 acetic acid 

Relevant academic research and scientific papers

Polycyclic compound for inhibiting RNA helicase DHX33

The invention relates to a polycyclic compound for inhibiting RNA helicase DHX33. In particular, the invention relates to a compound shown as a formula I or a pharmaceutically acceptable form thereof, a pharmaceutical composition containing the compound, a preparation method of the compound, and medical application of the compound to prevention and/or treatment of DHX33 related diseases.

Factors controlling the Selectivity of ipso-Attack in Homolytic Aromatic Substitutions. Reactions of Alkyl Radicals with Nitrothiophen Derivatives

The reactions of the nearly electroneutral methyl and of the nucleophilic 1-adamantyl radical with some selected nitrothiophen derivatives have been investigated in order to elucidate the factors which control the positional selectivity of radical addition to an aromatic substrate.With 5-nitro-2-X-thiophens (II), (V), and (VI) and 3,5-dinitro-2-methoxycarbonylthiophen (III) the adamantyl radical gave exclusively the products of ipso-attack, whereas the methyl radical selectively added at the unsubstituted 4-position.On the other hand, with 4-nitro-2-methoxycarbonylthiophen (I) both radicals added at the 5-position and with 4,5-dinitro-2-methoxycarbonylthiophen (IV) both radicals gave the products of ipso-substitution by displacing the nitro-group from the 5-position.These changes in positional selectivity are explained by assuming that the nature of the transition state of the addition step changes as a function of the polar character of the radical and of the electron deficiency of the aromatic substrates.