75748-52-6Relevant academic research and scientific papers
Multicomponent Synthesis of Isoindolinone Frameworks via RhIII-Catalysed in situ Directing Group-Assisted Tandem Oxidative Olefination/Michael Addition
Wang, Liang,Liu, Xi,Liu, Jian-Biao,Shen, Jun,Chen, Qun,He, Ming-Yang
supporting information, p. 765 - 769 (2018/03/07)
A RhIII-catalysed three-component synthesis of isoindolinone frameworks via direct assembly of benzoyl chlorides, o-aminophenols and activated alkenes has been developed. The process involves in situ generation of o-aminophenol (OAP)-based bidentate directing group (DG), RhIII-catalysed tandem ortho C?H olefination and subsequent cyclization via aza-Michael addition. This protocol exhibits good chemoselectivity and functional group tolerance. Computational studies showed that the presence of hydroxyl group on the N-aryl ring could enhance the chemoselectivity of the reaction.
Synthetic Control by Internal Interaction. The Intramolecular Diels-Alder Reactions of Furan Derivatives and α,β-Unsaturated Amides
Takebayashi, Toyonori,Iwasawa, Nobuharu,Mukaiyama, Teruaki
, p. 1107 - 1112 (2007/10/02)
An efficient method for the acceleration of the intramolecular Diels-Alder reaction was established utilizing the internal interaction - the internal hydrogen bonding and the internal coordination of a magnesium salt. The intramolecular Diels-Alder reacti
