86818-41-9

Upstream product

• 75748-52-6 N-(2-hydroxyphenyl)-2-furancarboxamide 
• 6078-02-0 2-furfurylideneamino-phenol 
• 98-01-1 furfural 
• 95-55-6 2-amino-phenol 
• 527-69-5 2-furancarbonyl chloride 

Downstream Products

• 86818-34-0 N-furfuryl-N-(2-hydroxyphenyl)-1-cyclohexanecarboxamide 
• 86818-35-1 Cyclopent-1-enecarboxylic acid furan-2-ylmethyl-(2-hydroxy-phenyl)-amide 
• 345931-42-2 N-furfuryl-N-(2-hydroxyphenyl)-1,5-cyclohexadienecarboxamide 

Relevant academic research and scientific papers

One-pot regioselective annulation toward 3,4-dihydro-3-oxo-2H-1,4-benzoxazine scaffolds under controlled microwave heating

An efficient and general synthesis of 2-alkyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazines under controlled microwave heating has been established. It consists of a microwave-assisted reductive N-arylmethylation of substituted 2-aminophenols with aromatic aldehy

Nitrogen-containing compound

A novel nitrogen-containing compound capable of preventing hardening of blood vessels by controlling formation of peroxide lipids in cell membranes, which is valuable as an anti-arteriosclerotic agent, is disclosed.

Synthesis of 3-Substitued Benzoxazoline-2-thiones

Several methods for the preparation of 3-substitued benzoxazoline-2-hiones (1) were examined.Method B via the thiation of 3-substitued benzoxazoline-2-one (5) with phosphorus pentasulfide was found to be applicable to the preparation of most analogs of 1, with a few expections.Method C via the cyclization of 2-(alkylamino)phenol (7) with potassium O-methyldithiocarbonate was suitable for the preparation of analogs with a group sensitive to high temperature of with an aryl- (including aromatic heterocyclic ring) methyl group.In addition, the reaction of benzoxazoline-2-thione (2) with acetals such as 1-ethoxyisochroman, 2-ethoxytetrahydrofuran, and ethoxytetraydropyran, or with Michael acceptors such as 2,3-dihydrofuran and 2H-3,4-dihydropyran, gave 3-substitued benzoxazoline-2-thione (1d-f).

Synthetic Control by Internal Interaction. The Intramolecular Diels-Alder Reactions of Furan Derivatives and α,β-Unsaturated Amides

An efficient method for the acceleration of the intramolecular Diels-Alder reaction was established utilizing the internal interaction - the internal hydrogen bonding and the internal coordination of a magnesium salt. The intramolecular Diels-Alder reacti