75804-53-4

Upstream product

• 18921-82-9 2,2-dimethyl-5-ethylidene-1,3-dioxane-4,6-dione 
• 57403-53-9 2,2-dimethyl-5-(1-phenylethylidene)-1,3-dioxane-4,6-dione 
• 1214-54-6 5-benzylidene Meldrum's acid 
• 1184-58-3 dimethylaluminum chloride 
• 75-16-1 methylmagnesium bromide 
• 2033-24-1 cycl-isopropylidene malonate 
• 98-85-1 1-Phenylethanol 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 34052-04-5 dimethyl 2-(1-phenylethyl)malonate 
• 1413943-31-3 5-hydroxy-2,2-dimethyl-5-(1-phenylethyl)-1,3-dioxane-4,6-dione 
• 1413942-87-6 5-hydroperoxy-2,2-dimethyl-5-(1-phenylethyl)-1,3-dioxane-4,6-dione 
• 1134-71-0 ethyl 3-phenylbutanoate 

Relevant academic research and scientific papers

Fe(HSO4)3 : An efficient, heterogeneous and reusable catalyst for C-alkylation of β-dicarbonyl compounds

Fe(HSO4)3(FHS) was used as an efficient catalyst for the heterogeneous addition of a series of benzylic and allylic alcohols to various β-dicarbonyl compounds, which afforded moderate to excellent yields of C-alkylated products in 1,2-dichloroethane. In comparison with the previous methods, the present research surprisingly exhibited higher reaction yields without formation of any by-products which could be formed by self-condensation of alcohols. Moreover, the catalyst can be readily recovered and reused up to five times with almost maintained reactivity and yields.

Probing persistent intramolecular C-H· · ·X(X = O, S, Br, Cl, and F) bonding in solution using benzyl meldrum's acid derivatives

Persistent intramolecular interactions between acidic C-H hydrogens and a variety of acceptors (X) (X = O, S, Br, Cl, and F) in solution were probed by 1H NMR experiments, using 5-benzyl Meldrum's acid derivatives. To bring about formation of i

Conjugate addition of dialkylaluminum chlorides to alkylidenemalonic acid derivatives

Complete regioselectivity is achieved in conjugate addition reactions of dialkylaluminum chlorides with alkylidenemalonic esters, alkylidenecyanoacetates, and alkylidenemalonodinitrile to give β-branched carboxylic acid derivatives. Sterically demanding products containing quaternary carbon atoms are obtained in good yields. In the case of diethylaluminum chloride, accompanying reductions of the substrates can be suppressed by application of boron trifluoride as an assisting Lewis acid.

ONE POT SYNTHESIS OF MONOSUBSTITUTED ISOPROPYLIDENE MALONATES

Monosubstituted isopropylidene malonates have been synthesized from Meldrum's acid and carbonyl compounds in the presence of sodium hydrogentelluride as a one pot reaction.

COPPER-CATALYZED CONJUGATE ADDITION OF GRIGNARD REAGENTS TO ISOPROPYLIDENE ALKYLIDENEMALONATES

A new method for the synthesis of isopropylidene alkylmalonates involving conjugate addition of Grignard reagents to isopropylidene alkylidene malonates was developed.