34052-04-5

Upstream product

• 17041-60-0 dimethyl ethylidenemalonate 
• 100-59-4 phenylmagnesium chloride 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 
• 544-97-8 dimethyl zinc(II) 
• 5660-63-9 4,4,5,5-tetramethyl-1,3-dioxolane 
• 109-99-9 tetrahydrofuran 
• 67-56-1 methanol 
• 75804-53-4 2,2-Dimethyl-5-(1-phenylethyl)-1,3-dioxane-4,6-dione 
• 1634-04-4 tert-butyl methyl ether 
• 585-71-7 (1-bromoethyl)benzne 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 80691-80-1 2-(1-phenylethyl)propane-1,3-diol 
• 1026736-33-3 2-{[(p-toluenesulfonyl)oxy]methyl}-3-phenylbutyl p-toluenesulfonate 

Relevant academic research and scientific papers

Probing persistent intramolecular C-H· · ·X(X = O, S, Br, Cl, and F) bonding in solution using benzyl meldrum's acid derivatives

Persistent intramolecular interactions between acidic C-H hydrogens and a variety of acceptors (X) (X = O, S, Br, Cl, and F) in solution were probed by 1H NMR experiments, using 5-benzyl Meldrum's acid derivatives. To bring about formation of i

Iron chloride enhancement of dimethylzinc-mediated radical conjugate addition of ethers and an amine to alkylidenemalonates

The addition of FeCl3 and the use of DMSO as a solvent enabled the radical conjugate addition of a cyclic acetal and a cyclic amine to alkylidenemalonates using a reagent amount (12.5 equiv) of the radical precursors to give Michael addition pr

Chemoselective conjugate addition of dimethylzinc-mediated ether and acetal radicals to alkylidenemalonates and asymmetric reactions

(Chemical Equation Presented) Cyclic and acyclic ether or acetal radicals were generated directly from ethers or acetals by the action of dimethylzinc-air, and their subsequent conjugate addition reaction with alkylidenemalonates afforded the corresponding conjugate adducts in reasonably high yields. The reaction with benzylidenemalonates bearing formyl and imino groups gave chemoselectively the conjugate addition products. The asymmetric reaction of bis(8-phenylmenthyl) benzylidenemalonate proceeded diastereoselectively to provide the adduct with 93:7 dr.

A one-pot preparation of 1,3-disubstituted azetidines

(Chemical Equation Presented) A straightforward synthesis of 1,3-disubstituted azetidines has been accomplished via the alkylation of a primary amine with the bis-triflate of a 2-substituted-1,3-propanediol species. This transformation is carried out in o