75825-37-5

Usage

InChI:InChI=1/C10H7N3O3/c11-6-8(10(12)14)5-7-3-1-2-4-9(7)13(15)16/h1-5H,(H2,12,14)/b8-5+

Upstream product

• 2826-30-4 2-(2-nitrobenzylidene)malononitrile 
• 552-89-6 2-nitro-benzaldehyde 
• 107-91-5 cyanoacetic acid amide 
• 7664-41-7 ammonia 
• 109-77-3 malononitrile 

Downstream Products

• 7152-39-8 amino-2 carboxamido-3 quinoleine N-oxyde 
• 106073-17-0 (±)-2-oxo-1,2,3,4-tetrahydroquinoline-3-carbonitrile 
• 1085941-04-3 C₃₇H₄₁N₅O₄ 
• 1085941-03-2 {3-[1-(3-benzyl-4-oxo-3,4-dihydro-pyrimido[4,5-b]quinolin-2-yl)-propylamino]-propyl}-carbamic acid tert-butyl ester 
• 1085941-02-1 3-benzyl-2-(1-bromo-propyl)-3H-pyrimido[4,5-b]quinolin-4-one 
• 1085941-01-0 3-benzyl-2-propyl-3H-pyrimido[4,5-b]quinolin-4-one 
• 31407-28-0 amino-2 carboxamido-3 quinoleine 

Relevant academic research and scientific papers

Synthesis of 2-cyanoacrylamides through Pd-catalyzed monohydration of methylenemalononitriles

A straightforward and efficient method has been developed for the synthesis of 2-cyanoacrylamide from 2-methylenemalononitriles through monohydration. A series of methylenemalononitriles underwent the reaction under mild and simple reaction conditions wit

Triflic acid-catalyzed metal-free synthesis of (: E)-2-cyanoacrylamides and 3-substituted azetidine-2,4-diones

A TfOH-catalyzed highly efficient synthesis of biologically active (E)-2-cyanoacrylamides and 3-substituted azetidine-2,4-diones has been reported with 64-94% yields under metal-free conditions. The reaction proceeds through sequential Knoevenagel condens

Cascade synthesis of 2-pyridones using acrylamides and ketones

Microwave assisted non-catalytic condensation of 2-cyanoacetamide with aromatic aldehydes, and enolate mediated Michael-type addition to acrylamide followed by oxidative cyclization, produce 2-pyridones in good to excellent yield. Unsymmetrical ketones produce two regioisomeric enolates, therefore thermodynamic and kinetic products of butan-2-one and pentan-2-one have been isolated and fully characterized. This journal is

Homogeneous and stereoselective copper(II)-catalyzed monohydration of methylenemalononitriles to 2-cyanoacrylamides

A facile and efficient route for the homogeneous and highly stereoselective monohydration of substituted methylenemalononitriles to (E)-2-cyanoacrylamides catalyzed by copper(II) acetate monohydrate in acetic acid containing 2% water is described, and a mechanism is proposed. The protocol has proved to be suitable for the monohydration of dicyanobenzenes and 2-substituted malononitriles.

Regiospecific Mno2 catalyzed hydration of phenylmethylene malononitriles to cyanophenylacrylamides by oximes

A novel and convenient method for the regiospecific hydration of phenylmethylene malononitriles to cyanoacrylamides was developed; Scope of the method and reaction conditions were optimized extensively, the method was found to be extremely successful in h

KINESIN INHIBITORS

This invention relates to the compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat a kinesin Eg5 protein-mediated disorder.

Knoevenagel condensation in heterogeneous phase catalyzed by IR radiation and Tonsil Actisil FF

Infrared radiation promoted the synthesis of benzylidenemalononitriles, benzylidenecyanoacetamides and benzylidenecyanoacetic acids by condensation of aromatic aldehydes with the corresponding active methylene compound in the presence of Tonsil Actisil FF, without solvent. Mass of catalyst, solvent, and reaction time were assessed in order to improve the efficiency of this process.

Preparation electrochimique de derives de la quinoleine. II. Electroreduction d'o-nitrobenzylidenes substitues

Quinoline N-oxydes and N-hydroxyquinolones have been prepared by controlled potential electrolysis of o-nitrobenzylidenes: o-NO2-C6H4-CH=CX2, o-NO2-C6H4-CH=CRX, o-NO2-C6H4-CH=CXY (X and Y being electron withdrawing groups: CO2Et, CN, CONH2, COPh).As a gen