75839-74-6

Upstream product

• 108-98-5 thiophenol 
• 112-67-4 n-hexadecanoyl chloride 
• 934-87-2 S-phenyl thioacetate 
• 57-10-3 1-hexadecylcarboxylic acid 
• 628-97-7 hexadecanoic acid ethyl ester 

Downstream Products

• 36653-82-4 1-Hexadecanol 
• 882-33-7 diphenyldisulfane 
• 1763-10-6 S-palmitoyl-coenzyme A 

Relevant academic research and scientific papers

Zinc promoted convenient and general synthesis of thiol esters

Synthesis of thiol esters from acyl chlorides and thiols in the presence of activated zinc is described. The recovery of zinc and its reuse makes the procedure more economic.

PROCESS FOR ACYL-TRANSFER ENZYME REACTIONS WITH ACYL- COENZYME A

The present invention relates to a method for acyltransferase reaction in which an acyl group of acyl coenzyme A is transferred to an acyl group receptor characterized in that the reaction is carried out by production and/or reproduction of acyl coenzyme A from coenzyme A in a reaction system by a chemical thioester exchange reaction with acylthioester. The present invention, wherein expensive acyl CoA is reproduced nonenzymatically in a reaction system, enables to continuously carry out acyltransferase reaction only by putting a small amount of acyl CoA with a donor and a receptor of an acyl group into a system. Accordingly, the method of the present invention can be applied to an industrial production method of various kinds of compounds including useful biological molecules and synthesis of polymers such as polyester.

Direct transformation of carboxyclic acids to thiol esters induced by phenyl dichlorophosphate

The condensation of carboxylic acids and thiols is greatly facilitated by the use of phenyl dichlorophosphate as an activating agent giving thiol esters in good yields.