75842-51-2

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 552-89-6 2-nitro-benzaldehyde 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 59436-13-4 2′-nitrostyrene methyl ether 
• 18362-49-7 1,3-bis(4-chlorophenyl)propane-1,3-dione 
• 88-73-3 2-Chloronitrobenzene 
• 873-73-4 4-n-chlorophenylacetylene 
• 609-73-4 o-nitroiodobenzene 
• 75848-38-3 (Z)-1-(4-Chloro-phenyl)-3-dimethylamino-2-(2-nitro-phenyl)-propenone 

Downstream Products

• 80805-57-8 1-(4-Chloro-phenyl)-2-(2-nitro-phenyl)-ethanone oxime 
• 1211-35-4 2-(4-chlorophenyl)-1H-indole 
• 81170-72-1 4-(4-chlorophenyl)-4,5-dihydro-2-ethyl-3-methyl-3H-1,3-benzodiazepine 
• 775237-89-3 [1-(4-Chloro-phenyl)-2-(2-nitro-phenyl)-ethyl]-methyl-amine 
• 757894-92-1 1-(4-Chloro-phenyl)-2-(2-nitro-phenyl)-ethylamine 
• 81170-71-0 4-(4-chlorophenyl)-4,5-dihydro-2,3-dimethyl-3H-1,3-benzodiazepine 
• 88057-42-5 2-[2-(4-Chloro-phenyl)-2-methylamino-ethyl]-phenylamine 
• 80805-60-3 1-(4-chlorophenyl)-2-(2-nitrophenyl)ethanone oxime acetate 
• 80805-80-7 N-[1-(4-Chloro-phenyl)-2-(2-nitro-phenyl)-ethyl]-formamide 

Relevant academic research and scientific papers

Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium saltsviaregioselective Heck arylation at room temperature

Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers.

Atroposelective Arene Formation by Carbene-Catalyzed Formal [4+2] Cycloaddition

Atroposelective arene formation is an efficient method to build axially chiral molecules with multi-substituted arenes. Reported here is an organocatalyzed atroposelective arene formation reaction by an N-heterocyclic carbene (NHC) catalyzed formal [4+2] cycloaddition of conjugated dienals and α-aryl ketones. This study expands the synthetic potential of NHC organocatalysis and provides a competitive pathway for the synthesis of axially chiral ligands, catalysts, and other functional molecules.

Palladium and copper catalyzed one-pot Sonogashira reaction of 2-nitroiodobenzenes with aryl acetylenes and subsequent regioselective hydration in water: Synthesis of 2-(2-nitrophenyl)-1-aryl ethanones

An attempted Sonogashira reaction of 2-nitroiodobenzene and phenyl acetylene catalyzed by Pd(PPh3)4/Cu in water in the presence of pyrrolidine proceeds with simultaneous regioselective hydration of the Sonogashira alkyne leading to the corresponding aryl ketone. A series of functionalized 2-(2-nitrophenyl)-1-aryl ethanones are obtained in high yields by this procedure.