59436-13-4Relevant academic research and scientific papers
Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium saltsviaregioselective Heck arylation at room temperature
Kandasamy, Jeyakumar,Lee, Yong Rok,Singh, Adesh Kumar,Venkatesh, Rapelly
supporting information, p. 7832 - 7837 (2021/09/28)
Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers.
Preparation of quinolines from resin-bound esters using titanium reagents
Macleod, Calum,Austin, Carolyn A.,Hamprecht, Dieter W.,Hartley, Richard C.
, p. 8879 - 8882 (2007/10/03)
ortho-Amino homobenzylic thioacetals are prepared from ortho- nitrobenzaldehydes via homologation using an alpha-methoxy Wittig reagent. Titanium reagents are generated from the 1,3-dithianes using a low valent titanium reagent and are then used to alkylidenate resin-bound esters. An N-silylated Boc group protects the ortho-amino functionality. Traceless SPS of quinolines is completed by treating the resulting resin-bound enol ethers with TFA and then oxidizing with manganese dioxide to give 2-substituted quinolines in high purity without the need for chromatography.
Microwave-assisted in situ deprotection and ω-methoxylation of TMS-protected aryl alkynes
Wettergren, Jenny,Minidis, Alexander B. E.
, p. 7611 - 7612 (2007/10/03)
Using microwave technology, rapid ω-methoxylation of aryl alkynes is possible.
