75865-16-6Relevant academic research and scientific papers
Visible Light-Mediated Decarboxylative Alkylation of Pharmaceutically Relevant Heterocycles
Sun, Alexandra C.,McClain, Edward J.,Beatty, Joel W.,Stephenson, Corey R. J.
, p. 3487 - 3490 (2018)
A net redox-neutral method for the decarboxylative alkylation of heteroarenes using photoredox catalysis is reported. Additionally, this method features the use of simple, commercially available carboxylic acid derivatives as alkylating agents, enabling the facile alkylation of a variety of biologically relevant heterocyclic scaffolds under mild conditions.
SOME NEW ASPECTS OF THIEPINE AND THIAZEPINE CHEMISTRY
Murata, Ichiro
, p. 243 - 260 (2007/10/02)
1) 1-Benzothiepineiron tricarbonyl was synthesized as a first example of thiepine-metal complex.On oxidation and decomplexation the complex gave 1-benzothiepine 1-oxide as thermally labile compound. 2) Thermolysis of a stable monocyclic thiepine gave the sulfur extruded benzene derivative together with the sulfurated product, the structure, the structure of which was confirmed by X-ray analysis. 3) The ring expansion reaction of 2,6-di-tert-butyl-4-azido-4-R-thiopyrans resulted in the formation of 1,3-thiazepine derivatives instead of the expected 1,4-thiazepines.
The Synthesis and Reactions of Sterically Constrained Pyrylium and Pyridinium Salts
Katritzky, Alan R.,Thind, Sukhpal S.
, p. 1895 - 1900 (2007/10/02)
Efficient syntheses are developed for several pyrylium cations with substitution patterns more sterically demanding than 2,4,6-triphenyl and these are examined as reagents for the conversion of primary amino into a leaving group.The 2-mesityl-4,6-diphenyl derivative did not react smoothly with amines.The 2,6-di-t-butyl-4-phenyl-pyrylium cation gave the corresponding pyridinium derivatives, but they resisted nucleophilic attack. 2-t-Butyl-4,6-diphenylpyridinium cations suffer nucleophilic attack with about the same ease as the 2,4,6-triphenyl analogues.Dihydrobenzopyrylium (6) and tetrahydrodibenzoxanthylium cations (7) gave pyridinium cations which underwent much easier nucleophilic attack: thus they alkylate xanthate anion in ethanol solution and acetate anion in acetic acid.
