75872-56-9

Upstream product

• 6705-49-3 7-oxabicyclo[4.1.0]heptan-2-one 
• 100-46-9 benzylamine 
• 66049-46-5 2-(p-nitrobenzoyloxy)-2-cyclohexen-1-one 
• 10316-66-2 2-hydroxy-2-cyclohexen-1-one 
• 765-87-7 cyclohexane-1,2-dione 

Downstream Products

• 121897-61-8 N-Benzyl-N-(6-oxo-cyclohex-1-enyl)-malonamic acid ethyl ester 
• 1008520-19-1 4-(1-Benzyl-7-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)-benzamide 
• 1008520-18-0 4-(1-Benzyl-7-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)-benzonitrile 
• 57310-61-9 (1S,6R,8S)-8-Phenyl-7-(toluene-4-sulfonyl)-7-aza-bicyclo[4.2.0]octan-5-one 
• 75682-59-6 N-benzyl p-toluenesulfonamido-2 cyclohexanone 
• 339986-66-2 N-benzyl-2-iodo-N-(6-oxo-1-cyclohexen-1-yl)acetamide 
• 306971-34-6 N-benzyl-2-chloro-N-(6-oxo-1-cyclohexen-1-yl)acetamide 
• 57310-56-2 N-benzyl p-toluenesulfonamido-2 cyclohexene-2 one 
• 75872-57-0 (2RS,3SR)-2-phenyl-1-aza-spiro[2.5]octan-4-one 

Relevant academic research and scientific papers

Multifaceted α-Enaminone: Adaptable Building Block for Synthesis of Heterocyclic Scaffolds Through Conceptually Distinct 1,2-, 1,3-, 1,4-, and C-O Bond Forming Annulations

The new reactivity of α,β-unsaturated enaminones driven by their dual electronic attitude is reported. We introduce unexplored, α-enaminone synthones and reveal the unusual functionalities of these building blocks. The feasibility of this new concept is demonstrated in the direct functionalization of enaminone precursors, such as alkylation; 1,2- 1,3-, or 1,4-addition; and C-O bond formation. The general and potential applicability is presented through the collective synthesis of several important classes of heterocycles via controlled cyclizations of easily accessible common precursors. The rapid composition of novel key α-enaminone synthones yields an assembly of oxazines, azaspirones, quinolinones, and quinolinols in a regio- and chemoselective fashion.

PROCESSES FOR THE PREPARATION OF HETEROCYCLIC SCAFFOLDS FROM ALPHA ENAMINONES

The present invention provides processes for the preparation of diverse heterocyclic scaffolds from alpha-enaminone building bloc of formula (I).

Preparation of N-arylamines from 2-oxo-7-azobicyclo[4.1.0]heptanes

A wide range of N-phenylated secondary amines were prepared directly from 2-oxo-7-azobicyclo[4.1.0]heptanes using 4-nitrobenzoic acid as acid catalyst. The intermediate enol esters could also be isolated under similar conditions. A catalytic cycle is proposed.

Benzene, Pyridine, and Pyridazine Derivatives

Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R31, and R41 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and

5-endo-trig radical cyclization of N-Benzyl-2-halo-N-(6-oxo-1-cyclohexen-1-yl) acetamides

N-Benzyl-2-halo-N-(6-oxo-1-cyclohexen-1-yl)acetamides, upon treatment with Bu3SnH in the presence of AIBN in boiling toluene, undergo 5-endo-trig radical cyclization to give (3aR*,7aR*)-N-benzyloctahydro-7a-hydroxyindole-2,7-dione in addition t