75959-46-5Relevant academic research and scientific papers
Reaction of Zinc Enolates of Alkyl Esters of Substituted 4-Bromo-3-Oxoalkanoic Acids with Aldehydes
Shchepin,Sazhneva,Litvinov
, p. 596 - 602 (2003)
Zinc enolates formed from ethyl 4-bromo-2,2,4-trimethyl-3-oxopentanoate react under the conditions of one- of two-stage synthesis with aliphatic, unsaturated, or aromatic aldehydes to form 6-R-2,2,4,4-tetramethyl-2,3,5,6- tetrahydropyran-2,4-diones. Zinc
Alkoxide-catalyzed ring expansion of 1,3-cyclobutanediones with aldehydes
Yamazaki, Mizuki,Yoshimura, Tomoyuki,Matsuo, Jun-ichi
supporting information, (2021/01/25)
1,3-Cyclobutanediones (dialkyl ketene dimer) reacted with various aromatic aldehydes to give six-membered cyclic β-keto esters by using a catalytic amount of potassium ethoxide. Effects of alkoxide catalysts and spiro cyclic groups at the 2,4-positions of 1,3-cyclobutanediones were investigated.
Powerful Claisen condensation and Claisen-aldol tandem reaction of α,α-dialkylated esters promoted by ZrCl4-iPr2NEt
Tanabe,Hamasaki,Funakoshi
, p. 1674 - 1675 (2007/10/03)
Powerful Claisen ester condensations of α,α-dialkylated esters mediated by ZrCl4-iPr2NEt were performed to give the corresponding thermodynamically unfavorable α,α-dialkylated β-ketoesters, and Claisen-aldol tandem reactions between an intermediary Zr-enolate of a α,α-dialkylated β-ketoester and aldehydes also proceeded.
Ethyl 3-Aryl-3-hydroxy-2,2-dimethylpropionates and 6-Aryl-3,3,5,5-tetramethyltetrahydropyran-2,4-diones
Unterhalt, Bernard,Weyrich, Klaus
, p. 795 - 799 (2007/10/02)
The chloroketones 1 react with equimolar amounts of a 10percent solution of sodium hydroxide in acetone to give the hydroxyketones 2.They were to be transformed into the substituted ethyl propionates 5 which are similar to clofibrate.As this synthesis fai
