78551-60-7

Basic information

• Product Name: 4-BENZYL-3-OXOPIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 4-BENZYL-3-OXOPIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-butyl 4-benzyl-3-oxopiperazine-1-carboxylate;4-(t-Butoxycarbonyl)-1-(phenylmethyl)piperazinone
• CAS NO: 78551-60-7
• Molecular Formula: C₁₆H₂₂N₂O₃
• Molecular Weight: 290.35748
• Mol File: 78551-60-7.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-BENZYL-3-OXOPIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZYL-3-OXOPIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(78551-60-7)
• EPA Substance Registry System: 4-BENZYL-3-OXOPIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(78551-60-7)

Safety Data

• Hazardous Substances Data: 78551-60-7(Hazardous Substances Data)

Usage

General Description

4-Benzyl-3-oxopiperazine-1-carboxylic acid tert-butyl ester is a compound that belongs to the class of piperazine carboxylic acid derivatives. It is a tert-butyl ester derivative of 4-benzyl-3-oxopiperazine-1-carboxylic acid, which is a carboxylic acid derivative that has potential use as a pharmaceutical intermediate. 4-BENZYL-3-OXOPIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER may have applications in the synthesis of various pharmaceuticals and bioactive molecules. It is important to handle this chemical with care as it may pose health and environmental hazards if not properly managed and disposed of.

Upstream product

• 100-39-0 benzyl bromide 
• 5625-67-2 2-Ketopiperazine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 57260-70-5 4-benzyl-piperazine-1-carboxylic acid tert-butyl ester 
• 76003-29-7 4-(t-butyloxycarbonyl)piperazin-2-one 
• 78551-58-3 1-(Phenylmethyl)piperazinone hydrochloride 
• 59702-21-5 1-benzyl-piperazin-2-one 
• 100-44-7 benzyl chloride 

Downstream Products

• 845544-11-8 C₃₉H₄₃F₂N₃O₄ 
• 875762-87-1 C₄₀H₅₀N₄O₇ 
• 875762-96-2 C₄₀H₄₉FN₄O₇ 
• 1261358-79-5 tert-butyl 4-benzyl-4,7-diazaspiro[2.5]octane-7-carboxylate 
• 611235-29-1 4-benzyl-4,7-diazaspiro[2.5]octane 
• 1261358-78-4 4-(4-benzyl-4,7-diaza-spiro[2.5]oct-7-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 886766-28-5 4,7-diazaspiro[2.5]octane-7-carboxylic acid tert-butyl ester 
• 1132841-39-4 (S)-4-benzyl-2-[(1S,2S)-2-(dibenzylamino)-1-hydroxy-3-phenylpropyl]-3-oxo-piperazine-1-carboxylic acid t-butyl ester 
• 875763-00-1 C₄₂H₄₈FN₃O₅ 
• 875783-07-6 C₃₇H₄₆FN₃O₆ 

Relevant articles and documents

Histamine H3 receptor antagonists with peptidomimetic (keto)piperazine structures to inhibit Aβ oligomerisation

Alzheime?s disease (AD) is the most prominent neurodegenerative disorder with high medical need. Protein-protein-interactions (PPI) interactions have a critical role in AD where β-amyloid structures (Aβ) build toxic oligomers. Design of disease modifying multi target directed ligand (MTDL) has been performed, which disable PPI on the one hand and on the other hand, act as procognitive antagonists at the histamine H3 receptor (H3R). The synthetized compounds are structurally based on peptidomimetic amino acid-like structures mainly as keto, diketo-, or acyl variations of a piperazine moiety connected to an H3R pharmacophore. Most of them showed low nanomolar affinities at H3R and some with promising affinity to Aβ-monomers. The structure–activity relationships (SAR) described offer new possibilities for MTDL with an optimized profile combining symptomatic and potential causal therapeutic approaches in AD.

INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE

The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY

Compound of formula (I′) or (I′′) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including ROR1 tyrosine kinase activity and may be used in the treatment of disorders associated with such activity.