76014-80-7

Usage

Uses

Used in Research Applications:
4-oxo-4-(3-pyridinebutanal) is used as a research compound for studying its properties and potential applications in various fields. As a metabolite of the tobacco-specific nitrosamine, NNK (Cat. #M32575), it plays a significant role in understanding the chemical processes and effects related to tobacco consumption.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-oxo-4-(3-pyridinebutanal) may be used as a starting material or intermediate in the synthesis of various drugs or drug candidates. Its unique chemical structure could potentially be exploited to develop new therapeutic agents.
Used in Chemical Synthesis:
4-oxo-4-(3-pyridinebutanal) can be used as a chemical intermediate in the synthesis of various organic compounds, particularly those with potential applications in the pharmaceutical, agrochemical, or materials science industries.

InChI:InChI=1/C9H9NO2/c11-6-2-4-9(12)8-3-1-5-10-7-8/h1,3,5-7H,2,4H2

Upstream product

• 626-55-1 3-Bromopyridine 
• 131684-97-4 1-(tert-butoxycarbonyl)-5-ethoxy-1-azacyclopentanone 
• 109065-57-8 3-(1,3-dioxolan-2-yl)-1-(pyridin-3-yl)propan-1-one 
• 59578-62-0 4-(3-pyridyl)-4-oxobutanol 
• 421557-52-0 3-(4,4-dimethoxy-1-oxobutyl)pyridine 
• 59-67-6 nicotinic acid 
• 95091-91-1 N-methoxy-N-methylpyridine-3-carboxamide 
• 16518-17-5 potassium nicotinate 

Downstream Products

• 487-19-4 nicotirine 
• 86900-39-2 3-(1-ethylpyrrolidin-2-yl)pyridine 
• 22083-74-5 3-(1-methyl-pyrrolidin-2-yl)-pyridine 
• 75652-51-6 3-(1-benzylpyrrolidin-2-yl)pyridine 
• 494-97-3 nornicotine 
• 3562-11-6 5'-carboxynornicotine 
• 5746-86-1 rac-nornicotine 

Relevant academic research and scientific papers

Methods of using QIAPINE

Uses of QIAPINE? to treat internal bleeding, such as subdural hematoma and subarachinoid hemorrhage, and ocular bleeding, such as such as hyphema and vitreous hemorrhage, in a subject are described. Also described are uses of QIAPINE? to treat vision loss resulting from hyphema or vitreous hemorrhage.

NH vs. CH hydrogen bond formation in metal-organic anion receptors containing pyrrolylpyridine ligands

Anion complexation studies on a series of platinum(II) tetrakis(pyrrolylpyridine) salts demonstrate the importance of CH-anion hydrogen bonds in coordinating anionic guests in solution and the solid-state. The Royal Society of Chemistry 2005.

Synthesis of nornicotine, nicotine and other functionalised derivatives using solid-supported reagents and scavengers

The sequential use of solid-supported reagents and scavengers has led to an efficient synthesis of the natural products nornicotine 1, nicotine 2 and further fuctionalised derivatives. Also reported is a diastereoselective route to both enantiomers of nicotine 2.

Synthesis of 15N-labelled nornicotine and 15N-labelled nicotine

The synthesis of 15N-labelled nornicotine 2 and 15N-labelled nicotine 1 is described via the reductive aminocyclization of a 1,4-ketoaldehyde with a corresponding amine in the presence of sodium cyanoborohydride. Yields of 30% and 26

A novel reductive aminocyclization for the syntheses of chiral pyrrolidines: Stereoselective syntheses of (S)-nornicotine and 2-(2'-pyrrolidyl)-pyridines

(S)-Nornicotine 2 was synthesized in four steps. A key step in the synthesis involved reductive aminocyclization of a 1,4-ketoaldehyde with 2,3,4,6-tetra-O-pivaloyl-β-D-galactosylamine 1 in the presence of sodium cyanoborohydride, diastereoselectively affording the corresponding stereoisomer 6 in 45% yield. The aminosugar moiety could be easily removed by acidic hydrolysis to furnish 2. The aminocyclization was further extended to asymmetric syntheses of novel chiral 2-(2'-pyrrolidyl)-pyridine ligands 12 and 13.

NEW METHODS FOR THE SYNTHESIS OF 2-ARYLPYRROLES

Two short and efficient synthetic approaches for -mostly unknown- 2-arylpyrroles are presented.The key intermediates 3 are conveniently obtained from commercially available acetophenones 5 (method I) or benzoic acid derivatives 10, 11 (method II).