76016-35-8

Basic information

• Product Name: N,N-Dimethyl2-(2-bromophenyl)acetamide
• Synonyms: N,N-Dimethyl2-(2-bromophenyl)acetamide;2-(2-Bromophenyl)-N,N-dimethylacetamide
• CAS NO: 76016-35-8
• Molecular Formula: C₁₀H₁₂BrNO
• Molecular Weight: 242.11
• Product Categories: alkyl bromide
• Mol File: 76016-35-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 331.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.377±0.06 g/cm3(Predicted)
• PKA: -0.65±0.70(Predicted)
• CAS DataBase Reference: N,N-Dimethyl2-(2-bromophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Dimethyl2-(2-bromophenyl)acetamide(76016-35-8)
• EPA Substance Registry System: N,N-Dimethyl2-(2-bromophenyl)acetamide(76016-35-8)

Safety Data

• Hazardous Substances Data: 76016-35-8(Hazardous Substances Data)

Usage

Uses

N,N-Dimethyl 2-(2-bromophenyl)acetamide

Upstream product

• 18698-97-0 ortho-bromophenylacetic acid 
• 55116-09-1 2-bromophenylacetyl chloride 
• 124-40-3 dimethyl amine 

Downstream Products

• 130198-58-2 1-[1-(2-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclohexanol 

Relevant articles and documents

2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: Synthesis and antidepressant activity

A series of 2-phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives was examined for the ability to inhibit both rat brain imipramine receptor binding and the synaptosomal uptake of norepinephrine (NE) and serotonin (5-HT). Neurotransmitter uptake inhibition was highest for a subset of 2-phenyl-2-(1-hydroxycyclohexyl)dimethylethylamines in which the aryl ring has a halogen or methoxy substituent at the 3- and/or 4-positions. Potential antidepressant activity in this subset was assayed in three rodent models - the antagonism of reserpine-induced hypothermia, the antagonism of histamine-induced ACTH release, and the ability to reduce noradrenergic responsiveness in the rat pineal gland. An acute effect seen in the rat pineal gland with several analogues, including 1-[1-(3,4-dichlorophenyl)-2-(dimethylamino)ethyl]cyclohexanol (23) and 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol (4), was taken as a possible correlate of a rapid onset of antidepressant activity. Compound 4 (venlafaxine) is presently undergoing clinical evaluation.

Process for preparation of o-(2,6-dichloroanilino)phenylacetic acid and novel intermediate for use in preparation of the same

Disclosed is a process for the preparation of o-(2,6-dichloroanilino)phenylacetic acid (Diclofenac) or its pharmacologically acceptable acid addition salt, which comprises hydrolyzing an N,N-disubstituted-o-(2,6-dichloroanilino)phenylacetamide derivative with an alkali. Also a novel intermediate for use in the preparation of Diclofenac, that is, an N,N-disubstituted-o-halogenophenylacetamide in which the halogen is iodine or bromine, is disclosed.