76019-87-9Relevant academic research and scientific papers
Dynamic kinetic asymmetric amination of alcohols: From a mixture of four isomers to diastereo- and enantiopure α-branched amines
Rong, Zi-Qiang,Zhang, Yao,Chua, Raymond Hong Bing,Pan, Hui-Jie,Zhao, Yu
supporting information, p. 4944 - 4947 (2015/05/05)
The first dynamic kinetic asymmetric amination of alcohols via borrowing hydrogen methodology is presented. Under the cooperative catalysis by an iridium complex and a chiral phosphoric acid, α-branched alcohols that exist as a mixture of four isomers undergo racemization by two orthogonal mechanisms and are converted to diastereo- and enantiopure amines bearing adjacent stereocenters. The preparation of diastereo- and enantiopure 1,2-amino alcohols is also realized using this catalytic system.
