760214-75-3Relevant academic research and scientific papers
GLYT2 MODULATORS
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Page/Page column 86, (2010/02/11)
α-, β-, and γ-amino acid derivatives of formula I are disclosed as selective GlyT2 inhibitors for the treatment of central nervous system (CNS) conditions such as muscle spasticity, tinnitus, epilepsy and neuropathic pain. Formula I
Novel glycine transporter type-2 reuptake inhibitors. Part 2: β- and γ-amino acid derivatives
Wolin, Ronald L.,Santillán Jr., Alejandro,Barclay, Tristin,Tang, Liu,Venkatesan, Hariharan,Wilson, Sandy,Lee, Doo Hyun,Lovenberg, Timothy W.
, p. 4493 - 4509 (2007/10/03)
Several β- and γ-amino acid derivatives were prepared as glycine transport inhibitors and their ability to block the uptake of [ 14C]-glycine in COS7 cells transfected with human glycine transporter-2 (hGlyT-2) were evaluated. A range of lipoph
