76043-83-9Relevant academic research and scientific papers
Synthesis of 3-arylcoumarins through N-heterocyclic carbene catalyzed condensation and annulation of 2-chloro-2-arylacetaldehydes with salicylaldehydes
Jiang, Yuansong,Chen, Wanzhi,Lu, Weimin
supporting information, p. 3669 - 3676 (2013/05/08)
The condensation reaction of 2-chloro-2-arylacetaldehyde with salicylaldehyde catalyzed by N-heterocyclic carbene (NHC) leading to 3-arylcoumarin was studied. A number of 3-arylcoumarin derivatives were obtained in good to excellent yields via this umpolung reaction. This reaction is facile and experimentally simple and mild.
2,2-DICHLOROALDEHYDES FROM ALDEHYDES AND ALCOHOLS BY CHLORINATION IN DIMETHYLFORMAMIDE
Buyck, L. De,Verhe, R.,Kimpe, N. De,Courtheyn, D.,Schamp, N.
, p. 441 - 458 (2007/10/02)
A method is described for the synthesis of α,α-dichloroaldehydes, free from monochloroaldehyde, by chlorination of aldehydes or alcohols in dimethylformamide at 40-90 deg C.Results are reported for : (yield percent) propanal (90), butanal (78), pentanal (78), 3-methylbutanal (90), propanol (64), butanol (78), 3-methylbutanol (52), pentanol (66), 3,3-dimethylbutanol (86), hexanol (66), 2-phenylethanol (51), 3-phenylpropanol (54), 1,5-pentanediol , 1,6-hexanediol .Oxidative conversion (KMnO4, K2Cr2O7, H2O2-NaHCO3) into α,α-dichlorocarboxylic acids and methyl esters is discussed.
