76047-51-3Relevant articles and documents
Cascade Radical Cyclization to Vinylogous Carbonates/Carbamates for the Synthesis of Oxa- and Aza-Angular Triquinanes: Diastereoselectivity Depends on the Ring Size of Radical Precursor
Gharpure, Santosh J.,Niranjana,Porwal, Suheel K.
, p. 2954 - 2967 (2018/07/21)
An efficient strategy was developed for the stereoselective construction of oxa- and aza-angular triquinanes employing a cascade 5 - exo - trig radical cyclization to vinylogous carbonates and carbamates. The radical precursors are readily prepared from 2-(hydroxymethyl)cyclopentenone/cyclohexenones. High diastereoselectivity is observed for the formation of angular oxa- and azatriquinanes. Diastereoselectivity drops when six-membered radical precursors are used. The strategy is found to be useful to incorporate synthetically challenging moieties such as spiroindoline, lactone-bearing, and uracil-fused angular triquinanes in a concise manner.
Multi-component assembly of the bicyclic core associated with the tRNA synthetase inhibitors SB-203207 and SB-203208. Application to the synthesis of biologically active analogues
Banwell,Crasto,Easton,Karoli,March,Nairn,O'Hanlon,Oldham,Willis,Yue
, p. 2210 - 2211 (2007/10/03)
The ketone (±)-5, which embodies the bicyclic core associated with the title tRNA synthetase inhibitors 1 and 2, has been prepared via a three-component coupling reaction involving 2-(hydroxymethyl)cyclopent-2-enone (15), methylamine (6) and propiolamide
A stereospecific total synthesis of (±)-epipentenomycin I, (±)-epipentenomycin II and (±)-epipentenomycin III
Smith III,Pilla
, p. 4691 - 4694 (2007/10/02)
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