76052-78-3

Basic information

• Product Name: 2(1H)-Quinoxalinone,5-methyl-(9CI)
• Synonyms: 2(1H)-Quinoxalinone,5-methyl-(9CI)
• CAS NO: 76052-78-3
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• Product Categories: QUINOXALINE
• Mol File: 76052-78-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(1H)-Quinoxalinone,5-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone,5-methyl-(9CI)(76052-78-3)
• EPA Substance Registry System: 2(1H)-Quinoxalinone,5-methyl-(9CI)(76052-78-3)

Safety Data

• Hazardous Substances Data: 76052-78-3(Hazardous Substances Data)

Usage

Chemical Class

Quinoxalinone derivatives

Key Structural Feature

Quinoxaline ring with a methyl substituent at the 5th position

Potential Applications

Pharmaceutical industry (development of novel drugs and medications)

Other Possible Uses

Research and chemical synthesis processes

Additional Information

Further studies and research needed to fully understand and explore the potential properties and applications of this compound.

Upstream product

• 874499-60-2 8-methyl-3-oxo-3,4-dihydro-quinoxaline-2-carboxylic acid 
• 298-12-4 Glyoxilic acid 
• 2687-25-4 3-methyl-1,2-benzenediamine 
• 924-44-7 glyoxylic acid ethyl ester 
• 874499-59-9 8-methyl-3-oxo-3,4-dihydro-quinoxaline-2-carboxylic acid ethyl ester 
• 570-24-1 2-Methyl-6-nitroaniline 
• 191847-67-3 N-(2-methyl-6-nitrophenyl)glycine 

Downstream Products

• 718615-10-2 5-methyl-quinoxalin-2-ylamine 
• 119059-58-4 sulfanilic acid-(5-methyl-quinoxalin-2-ylamide) 
• 875257-59-3 N-acetyl-sulfanilic acid-(5-methyl-quinoxalin-2-ylamide) 
• 61148-17-2 2-chloro-5-methylquinoxaline 

Relevant articles and documents

Synthesis of (E)-Quinoxalinone Oximes through a Multicomponent Reaction under Mild Conditions

Herein, a novel method for the gram-scale synthesis of (E)-quinoxalinone oximes through a multicomponent reaction under mild conditions is described. Such a transformation was performed under transition-metal-free conditions, affording (E)-oximes in a moderate-to-good yield through recrystallization. Our methodology demonstrates a successful combination of a Mannich-type reaction and radical coupling, providing a green and practical approach for the synthesis of potentially bioactive quinoxalinone-containing molecules.

N, N, N', N'-Tetramethylethylenediamine-Enabled Photoredox-Catalyzed C-H Methylation of N-Heteroarenes

Aiming at the valuable methylation process, readily available and inexpensive N,N,N′,N′-tetramethylethylenediamine (TMEDA) was first identified as a new methyl source in photoredox-catalyzed transformation in this work. By virtue of this simple methylating reagent, a facile and practical protocol for the direct C-H methylation of N-heteroarenes was developed, featuring mild reaction conditions, broad substrate scope, and scalability. Mechanistic studies disclosed that a sequential photoredox, base-assisted proton shift, fragmentation, and tautomerization process was essentially involved.

Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines

Several phenyl substituted naphthalenes and isoquinolines have been identified as antibacterial agents that inhibit FtsZ-Zing formation. In the present study we evaluated the antibacterial of several phenyl substituted quinoxalines, quinazolines and 1,5-naphthyridines against methicillin-sensitive and methicillin-resistant Staphylococcus aureus and vancomycin-sensitive and vancomycin-resistant Enterococcus faecalis. Some of the more active compounds against S. aureus were evaluated for their effect on FtsZ protein polymerization. Further studies were also performed to assess their relative bactericidal and bacteriostatic activities. The notable differences observed between nonquaternized and quaternized quinoxaline derivatives suggest that differing mechanisms of action are associated with their antibacterial properties.