760949-08-4Relevant academic research and scientific papers
A convenient synthesis of 9H-thioxanthen-9-ones and their aza-analogues
Kobayashi, Kazuhiro,Komatsu, Toshihide,Nakagawa, Kazuhiro,Hara, Erika,Yuba, Shohei
, p. 2577 - 2587 (2013)
An efficient method for the preparation of 9H-thioxanthen-9-ones and their three aza-analogues has been developed. The reaction of (2-fluorophenyl)(2- halophenyl)methanones, derived from 1-bromo-2-fluorobenzenes and 2- halobenzaldehydes by an easy two-step sequence, with Na2S· 9H2O in DMF at 60 °C gives 9H-thioxanthen-9-ones. This procedure can be applied to the synthesis of 5H-[1]benzothiopyrano[2,3-b](or [2,3-c])pyridin-5-ones or 10H-[1]-benzothiopyrano[3,2-c]pyridin-10-ones starting from 2-, 3- or 4-chloropyridines, respectively.
Pyridines and Pyrimidines Mediating Activity against an Efflux-Negative Strain of Candida albicans through Putative Inhibition of Lanosterol Demethylase
Buurman, Ed T.,Blodgett, April E.,Hull, Kenneth G.,Carcanague, Daniel
, p. 313 - 318 (2007/10/03)
The first step in ergosterol biosynthesis in Saccharomyces cerevisiae consists of the condensation of two acetyl coenzyme A (acetyl-CoA) moieties by acetoacetyl-CoA thiolase, encoded by ERG10. The inhibition of the sterol pathway results in feedback activ
