76104-56-8

Upstream product

• 264121-27-9 3-(2,4-dimethoxyphenyl)propanoi acid isopropyl ester 
• 848081-07-2 3-(2',4'-dimethoxyphenyl)propionaldehyde 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 54771-59-4 (Z)-3-(2,4-Dimethoxy-phenyl)-prop-2-en-1-ol 
• 16909-09-4 (E)-3-(2,4-dimethoxyphenyl)-2-propenoic acid 
• 22174-28-3 methyl-3-(2,4-dimethoxyphenyl)propanoate 
• 300767-53-7 2-[(Z)-3-hydroxy-1-propenyl]-5-methoxyphenol 
• 531-59-9 7-methoxycoumarin 
• 22174-29-4 3-(2,4-dimethoxyphenyl) propionic acid 

Downstream Products

• 106800-26-4 3-(2-hydroxy-4-methoxyphenyl)propanol 
• 106800-27-5 3-(4-hydroxy-2-methoxyphenyl)propanol 
• 848081-07-2 3-(2',4'-dimethoxyphenyl)propionaldehyde 
• 221054-79-1 (+)-Equol 
• 531-95-3 equol 
• 106800-32-2 3-(3-hydroxy-2,4-dimethoxyphenyl)propanol 
• 83156-20-1 (S)-5-{(S)-[2,4-Dimethoxy-5-(3-methoxy-propyl)-phenyl]-methoxy-methyl}-2,2,4,4-tetramethyl-[1,3]dioxolane 
• 83156-15-4 [2,4-Dimethoxy-5-(3-methoxy-propyl)-phenyl]-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-methanone 
• 83156-16-5 (S)-[2,4-Dimethoxy-5-(3-methoxy-propyl)-phenyl]-((S)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-methanol 
• 83156-14-3 1-Bromo-2,4-dimethoxy-5-(3-methoxy-propyl)-benzene 
• 36680-47-4 di-methyl ether of 4-n-propyl resorcinol 

Relevant academic research and scientific papers

A Concise Enantiodivergent Synthesis of Equol

Equol, a nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein, has been synthesized as both enantioenriched forms based on MacMillan's α-Arylation of carbonyl compound mediated by amino acid derived indazolidinones and copper precatalysts. The natural form of (S)-equol and its enantiomer (R)-equol have been synthesized in 8 steps from 2,4-dimethoxybenzaldehyde with good enantiomeric purity (90% ee and 90% ee, respectively).

Optimized 4,5-diarylimidazoles as potent/selective inhibitors of Protein Kinase CK1δ and their structural relation to P38α MAPK

The involvement of protein kinase CK1δ in the pathogenesis of severe disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, familial advanced sleep phase syndrome, and cancer has dramatically increased interest in the development of effecti

5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES

The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I),wherein X represents CH2 or O; R1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl; R2 represents (C1-4)alkyl, (C1-4)alkoxy, (C2-4)alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR5R6 or cyclopropyl; R3 represents (C1-4)alkyl, (C1-4)alkoxy-methyl or halogen; R4 represents (C1-4)alkyl; R5 represents hydrogen or (C1-4)alkyl; and R6 represents hydrogen or (C1-4)alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds; and to the use of such compounds as medicaments; especially as orexin receptor antagonists.

Synthesis and biological studies of novel 2-aminoalkylethers as potential antiarrhythmic agents for the conversion of atrial fibrillation

A series of 2-aminoalkylethers prepared as potential antiarrhythmic agents is described. The present compounds are mixed sodium and potassium ion channel blockers and exhibit antiarrhythmic activity in a rat model of ischemia-induced arrhythmias. Structure-activity studies led to the identification of three compounds 5, 18, and 26, which were selected based on their particular in vivo electrophysiological properties, for studies in two canine atrial fibrillation (AF) models. The three compounds converted AF in both models, but only compound 26 was shown to be orally bioavailable. Resolution of the racemate 26 into its corresponding enantiomers 40 and 41 and subsequent biological testing of these enantiomers led to the selection of (1S,2S)-1-(1-naphthalenethoxy)-2-(3- ketopyrrolidinyl)cyclohexane monohydrochloride (41) as a potential atrial selective antiarrhythmic candidate for further development.

Synthesis of C-alkylcalix[4]arenes, 6. - The interaction of resorcin[4]arenes with Fe(III) in chloroform

Resorcinarene octamethyl ethers, bearing carboalkyloxy groups in the side chains, have been shown to interact with Fe(III) in organic media. 1H- NMR studies, carried out using Ga(III) instead of Fe(III), suggest that these systems have two active sites of interaction, the first located at the aromatic moiet and the other in the vicinity of the carbonyl groups. As a confirmation of this, resorcinarenes without carbonyl groups in the side chains have been found to exhibit only one active site. Notably, in the latter case the interaction results in configurational changes.

Hydroxyl-Directed Regioselective Monodemethylation of Polymethoxyarenes

Methoxyl groups ortho to β-hydroxyethyl or γ-hydroxypropyl substituents in polymethoxybenzene derivatives were regioselectively demethylated with sodium thioethoxide in N,N-dimethylformamide.Methoxydihydrobenzofurans or methoxychromans were produced by cyclization of the monodemethylated β-hydroxyethyl or γ-hydroxypropyl derivatives, respectively.