761401-97-2Relevant academic research and scientific papers
Directed ring-closing metathesis of trienes by silyl substitution
Schultz-Fademrecht, Carsten,Deshmukh, Prashant H.,Malagu, Karine,Procopiou, Panayiotis A.,Barrett, Anthony G.M.
, p. 7515 - 7524 (2007/10/03)
A synthetic strategy for 'disarming' a terminal alkene by substitution with a bulky silyl blocking group has been developed. In a series of model studies, sequential selective ring-closing metathesis of trienes followed by selective mono-hydrogenation of the resulting diene is described. The bulky silylated alkene is activated for a subsequent cross-metathesis reaction with a range of diverse alkenes by protodesilylation.
