761402-24-8

Upstream product

• 66370-75-0 methyl (2-iodophenyl)acetate 
• 829-85-6 diphenylphosphane 
• 18698-96-9 o-iodophenylacetic acid 
• 5931-53-3 Diphenyl-o-tolylphosphin 
• 1079-66-9 chloro-diphenylphosphine 
• 95-46-5 2-methylphenyl bromide 
• 67-56-1 methanol 
• 201011-35-0 2-[2-(diphenylphosphino)phenyl]acetic acid 

Downstream Products

• 1041861-43-1 C₂₆H₃₀NO₂P 
• 1041861-45-3 C₂₈H₂₆NO₂P 
• 1041861-42-0 C₂₅H₂₈NO₂P 

Relevant academic research and scientific papers

Palladium-Catalyzed Asymmetric Decarboxylative [4+2] Dipolar Cycloaddition of 4-Vinyl-1,3-dioxan-2-ones with α,β-Disubstituted Nitroalkenes Enabled by a Benzylic Substituted P,N-Ligand

The Pd-catalyzed asymmetric [4+2] cycloaddition reaction of an aliphatic 1,4-dipole with singly activated electron-deficient alkenes is realized for the first time, enabled by using a newly developed benzylic substituted P,N-ligand, affording tetrahydropyrans having three continuous chiral centers in high yields with high diastereo-and enantioselectivities. The rational transition states of the reaction as well as the role of the benzylic chiral center are proposed.

A dramatic switch of enantioselectivity in asymmetric heck reaction by benzylic substituents of ligands

A series of benzylic substituted P,N-ligands 1 and 2 have been synthesized. The Pd-complexes of these ligands show high catalytic activity and enantioselectivity in catalyzing the asymmetric Heck reaction. A dramatic switch in enantioselectivity is realized using ligands with and without substituents at the benzylic position of the ligand. Ligands 1 with H as the substituents offer products in (R)-configuration while ligands 2 with the methyl as substituents result in (S)-configuration products. In most cases high enantioselectivities are achieved. Density functional theory calculations on the reaction mechanism as well as X-ray analysis of 1a-PdCl2 and 2a-PdCl2 complexes provide a rational explanation for the above observations.

Synthesis of new chiral benzylically substituted P,N-ligands and their applications in the asymmetric Heck reaction

A series of new chiral P,N-ligands with substituents at the benzylic position has been prepared. Their high catalytic activity is shown in the Pd-catalyzed asymmetric Heck reaction and allylic substitution reaction.