761414-79-3

Basic information

• Product Name: KR-62436
• Synonyms: 6-{2-[(5-Cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile dihydrochloride hydrate;KR-62436 hydrate
• CAS NO: 761414-79-3
• Molecular Weight: 297.319
• Mol File: 761414-79-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: KR-62436(CAS DataBase Reference)
• NIST Chemistry Reference: KR-62436(761414-79-3)
• EPA Substance Registry System: KR-62436(761414-79-3)

Safety Data

• Hazardous Substances Data: 761414-79-3(Hazardous Substances Data)

Upstream product

• 202460-48-8 6-[(2-aminoethyl)amino]pyridine-3-carbonitrile 
• 761414-68-0 2-chloroacetyl-3,4-dihydro-2H-pyrazole-3-carbonitrile 

Relevant articles and documents

Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents

A new series of cyano-pyrazoline derivatives with secondary amine at P-2 site was synthesized through achiral and chiral synthetic methods and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV). Compound 5i revealed good in vivo efficacy (ED50: 4.1mg/kg; in vivo DP-IV inhibition). Also chiral derivative (11b) having (S)-configuration of compound 5i was found to be more potent.