76142-13-7

Upstream product

• 1521-61-5 1,3,5-trimethoxy-2,4-dimethyl benzene 
• 21722-31-6 1-(2-hydroxy-4,6-dimethoxy-3,5-dimethylphenyl)ethanone 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 76142-16-0 2'-hydroxy-4,4',6'-trimrthoxy-3',5'-dimethyldihydrochalcone 
• 74805-86-0 methylophiopogonone B monomethyl ether 

Relevant academic research and scientific papers

Total Syntheses of 4′,6′-Dimethoxy-2'-Hydroxy-3′,5′-Dimethylchalcone Derivatives

Chalcone derivatives afford several pharmacological activities. However, a general synthetic method for 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC) derivatives has not been reported thus far. To address this, the preparation of 4',6'-dimethoxy-2'-hydroxy-3',5'-dimethylchalcone (MDMC) derivatives, modified compounds of DMC, in excellent overall yields is reported herein. These compounds have recently attracted growing attention due to their various pharmacological activities. Di-O-methyl-dimethylphloroacetophenone, the key intermediate containing the B-ring moiety, was fabricated by four efficient reaction steps from commercially available phloroglucinol in a 50.1% isolated yield overall. Our synthetic route, which constructs the chalcone skeleton in the final stage via a Claisen–Schmidt condensation of the key intermediate with the desired benzaldehyde derivative, can rapidly produce a vast library of DMC derivatives.

DIMETHYLCHALCONE DERIVATIVES AND PREPARATION METHOD THEREOF

The present invention relates to a dimethalcone (DMC) derivative and a method for producing the same. A compound according to an embodiment of the present invention is represented by chemical formula I: [Chemical Formula I]. In Formula I, R1, R2, and R3 are the same as or different from each other, R1 is a hydroxy group or a methoxy group, R2, and R3 are each independently hydrogen, deuterium, a nitro group, a hydroxyl group, a carbonyl group C1?C10, a nitro group, C1?C10 a hydroxyl group, an 'C2?C10 alkyloxy group', an aryloxy C2?C10 group, an aryloxy group, an alkylthioxy group, a silyl group, a boron group, an alkyl group or an C6?C20 aryl group. (C1?C10. The cycloalkyl group, alkenyl group, alkynyl group, aryl group, aralkyl group, aralkyl group, alkylaryl group, alkylamine group. The substituent may be substituted or unsubstituted with 1 or more substituents selected from the group consisting of an aralkylamine group, a heteroarylamine group, an arylamine group, an arylphosphine group, and a heterocyclic group.

First synthesis of racemic methylophiopogonanone B and its inhibitory activity of hypoxia-inducible factor-1α

Methylophiopogonanone B, a constituent of Ophiopogonis tuber, found to be a potent inhibitor of hypoxia induced factor-1 α (HIF-1 α) activity, was synthesized from 2,4,6-trihydroxy-3,5-dimethylacetophenone in 57% yield. The synthetic methylophiopogonanone

STUDIES ON THE CONSTITUENTS OF OPHIOPOGONIS TUBERS. VII. SYNTHETIC STUDIES OF HOMOISOFLAVONIDS.

Several homoisoflavonoidal compounds, namely the monomethyl ethers ((IIIb) and (IVb)) of methylophiopogonones A and B, isoophiopogonone A monomethyl ether (VIIIb) and desmethylisoophiopogonone B (IXa), which were derived from the constituents of Ophiopogo