76142-63-7

Usage

InChI:InChI=1/C11H19NO2S/c1-11(2,3)12-6-9(13)7-14-10-4-5-15-8-10/h4-5,8-9,12-13H,6-7H2,1-3H3

Upstream product

• 76142-58-0 1-(3-thienyloxy)-2,3-epoxypropane 
• 75-64-9 tert-butylamine 
• 76142-54-6 1-(3-thienyloxy)-2,3-O-isopropylidene propane 
• 177974-47-9 3-(2,3-dihydroxy)propoxythiophene-2-carboxylic acid 
• 76142-56-8 3-(3-thienyloxy)-1,2-propanediol 

Relevant academic research and scientific papers

Synthesis and antiplatelet activity of 1-tert-butylamino-3-(3-thienyloxy)-2-propanols

The synthesis of new 1-tert-butylamino-3-(3-thienyloxy)-2-propanols by two alternative methods is described. Their initial antiplatelet activity evaluation against ADP, adrenaline, and collagen is reported, and the preliminary structure-activity relations

Synthesis and β-adrenoceptor blocking activity of thiophenic analogues of toliprolol and bevantolol and closely related compounds

The synthesis of a series of 3-alkylamino-1-thienyloxy-2-propanols starting from isopropylideneglycerol and the corresponding bromothiophene is described. In a preliminary pharmacological study compound 14 is very similar to Propranolol, while compound 13, a thiophenic isoster of Toliprolol seems to be less active. On the other hand compound 15, and isoster of cardioselective Bevantolol appears to be also a cardioselective β-blocking agent.