76143-84-5

Usage

Uses

Used in Pharmaceutical Synthesis:
Isoquinoline, 7-methoxy-1-methylis employed as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a versatile building block for the development of new drugs with potential therapeutic benefits.
Used as a Precursor in Chemical Production:
Isoquinoline, 7-methoxy-1-methylalso serves as a precursor in the production of other chemicals, highlighting its importance in the chemical industry and its ability to be transformed into a variety of useful products.
Used in Medicinal Research:
Isoquinoline, 7-methoxy-1-methylhas been studied for its potential medicinal properties, including its reported anti-inflammatory and anticonvulsant effects. Its exploration in medicinal research underscores the interest in discovering new therapeutic agents from existing chemical compounds.

Upstream product

• 39989-39-4 7-methoxyisoquinoline 
• 67-68-5 dimethyl sulfoxide 
• 108-05-4 vinyl acetate 
• 1257846-26-6 (E)-1-(3-methoxyphenyl) ethanone O-acetyl oxime 
• 51673-84-8 dimethoxyacetaldehyde 
• 854184-18-2 (+/-)-1-(3-methoxyphenyl)ethylamine hydrochloride 
• 122806-25-1 1-(3-methoxy-phenyl)-ethanone oxime 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 61190-04-3 (2,2-Diethoxy-ethyl)-[1-(3-methoxy-phenyl)-meth-(Z)-ylidene]-amine 
• 76143-78-7 [1-(3-methoxy-phenyl)-ethylamino]-acetaldehyde diethylacetal 

Downstream Products

• 81593-51-3 1,2,3,4-tetrahydro-7-methoxy-1-methyl-2-<4-(3,4-dimethoxybenzoyloxy)butyl>isoquinoline hydrochloride 
• 140683-34-7 7-Methylamino-1-methylisoquinoline 
• 31181-23-4 1-methyl-7-hydroxyisoquinoline 
• 81593-62-6 7-methoxy-1-methyl-2-<4-(3,4-dimethoxybenzoyloxy)butyl>isoquinolinium iodide 

Relevant academic research and scientific papers

Synthesis and SAR Studies of Isoquinoline and Tetrahydroisoquinoline Derivatives as Melatonin Receptor Ligands

In our constant search for new successors of agomelatine, we report herein a new series of compounds resulting from bioisosteric modulation of the naphthalene ring. The isoquinoline and tetrahydroisoquinoline derivatives were synthesized and pharmacologic

Isoquinoline synthesis by C-H activation/annulation using vinyl acetate as an acetylene equivalent

Vinyl acetate is used as an acetylene equivalent in rhodium(III)-catalysed C-H activation/annulation with aryl ketoxime esters. Extension to an aldoxime ester allows for a concise formal synthesis of decumbenine B.

Reaction of isoquinoline 2-oxides with methylsulfinylmethyl carbanion

7-Methoxy-3-methylsulfonyl-3H-benz[d]azepine (5) and 2-deuterio-3-(methyl-d3)-sulfonyl-3H-benz[d]azepine (14) were obtained from the reaction of the corresponding isoquinoline 2-oxides with methylsulfinylmethyl carbanion. A revised reaction mechanism is proposed on the basis of the results obtained by use of deuterated dimethyl sulfoxide-d6.

Method of producing alpha2 antagonism

Method of producing alpha2 antagonism by administering thiadiazolo- and oxadiazolotetrahydroisoquinoline compounds.

Inhibiting phenylethanolamine N-methyltransferase with thiadiazolo and oxadiazolotetrahydroisoquinolines

Thiadiazolo- and oxadiazolotetrahydroisoquinoline compounds are inhibitors of phenylethanolamine N-methyltransferase.

A ONE-POT ISOQUINOLINE SYNTHESIS BY CYCLODEHYDROGENATION OF BENZYLAMINOACETALS WITH CHLOROSULFONIC ACID

A direct preparation of the fully aromatized isoquinolines (3a-l) by the cyclodehydrogenation of benzylamnoacetals (2a-l) with chlorosulfonic acid is described.Comparing the behavior of chlorosulfonic acid with that of sulfuric acid toward 1,2-dihydroisoquinoline, it is able to be suggested that benzylaminoacetals were cyclized first to 1,2-dihydroisoquinolines, subsequently, dehydrogenated to the fully aromatized isoquinolines by the hydride abstraction with ClSO3H.Subtitution by a larger R3 group than isopropyl in the acetal ArCH(R3)NHCH2CH(OEt)2, interfered this second step, so the corresponding isoquinolines could not be obtained.