7617-95-0

Usage

Chemical structure

1-Fluoro-1-deoxy-beta-D-glucose is a synthetic chemical compound that is structurally similar to glucose, with a fluorine atom added at the 1 position.

Primary use

It is used in medical imaging studies, particularly in positron emission tomography (PET) scans.

Imaging capabilities

The fluorine atom enables the compound to be traced and visualized within the body.

Information provided

It provides valuable information about glucose metabolism and distribution.

Applications

It is a valuable tool for studying various diseases and conditions, including cancer, diabetes, and neurological disorders.

Versatility

The compound's ability to mimic glucose and its enhanced imaging capabilities make it an important and versatile tool in medical research and diagnostics.

Upstream product

• 439-03-2 2-(acetoxymethyl)-6-fluorotetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 221252-41-1 1,3,4,6-tetra-O-acetyl-2-O-methanesulfonyl-β-D-mannose 
• 18968-05-3 1,3,4,6-tetra-O-acetyl-β-D-mannopyranose 
• 221252-44-4 2-O-methanesulfonyl-β-D-mannose 

Downstream Products

• 492-61-5 β-D-glucose 
• 492-62-6 alpha-D-glucopyranose 
• 34627-06-0 α-D-glucopyranosyl α-D-xylopyranoside 
• 99-20-7 TREHALOSE 
• 29074-00-8 2,2,2-Trifluoroethyl β-D-glucopyranoside 
• 29074-00-8 2,2,2-Trifluoroethyl α-D-glucopyranoside 
• 3198-49-0 (2R,3R,4S,5S,6R)-2-Ethoxy-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol 
• 3198-49-0 ethyl α-D-glucopyranoside 
• 97-30-3 methyl-alpha-D-glucopyranoside 
• 3482-57-3 p-nitrophenyl-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranoside 
• 72647-96-2 4-nitrophenyl α-isomaltoside 
• 3150-20-7 4-methoxyphenyl β-D-glucopyranoside 
• 71117-37-8 (2R,4aR,6R,7R,8R,8aS)-6-Methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol 
• 124152-16-5 O²,O³,O⁴-triacetyl-O⁶-trityl-β-D-glucopyranosyl fluoride 

Relevant academic research and scientific papers

Creation of an α-mannosynthase from a broad glycosidase scaffold

α-Mannosides made easy: Mutation of a family-GH31 α-glucosidase that displays plasticity to alterations at the 2-OH position of donor substrates created an efficient α-mannoside-synthesizing biocatalyst. A simple fluoride donor reagent was used for the synthesis of a range of mono-α-mannosylated conjugates using the α-mannosynthase displaying low (unwanted) oligomerization activity. Copyright

Synthesis of 1-[18F]fluorodeoxyglucose: An unexpected rearrangement in the reaction of 2-O-methanesulfonyl-β-D-mannopyranose with [18F]fluoride

2-O-Methanesulfonyl-β-D-mannose was reacted with kryptofix/K2CO3/[18F]fluoride in CH3CN/THF (9:1) at 60°C. Unexpectedly, a mixture of 1α- and 1β-glucopyranosyl [18F]fluoride (4 and 5, respectively) was obtained in 50% radiochemical yield (EOB); 2-[18F]FDG was not detected. Modification of temperature, solvent or pH did not result in the formation of 2-[18F]FDG. Uptake of radioactivity in heart and brain of mice was significantly lower for 4 and 5 than for 2-[18F]FDG, although 5 seems to pass the blood-brain barrier. Uptake in bone was more pronounced for 4 than for 5 and negligible for 2-[18F]FDG.