76175-41-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(benzylamino)-1-(thien-2-yl)ethanol is used as a potential pharmaceutical compound for its amine and alcohol functionalities, which could be harnessed in drug synthesis. The presence of the thiophene ring may also contribute to its bioactivity, making it a candidate for the development of new medications.
Used in Drug Synthesis:
2-(benzylamino)-1-(thien-2-yl)ethanol is used as a building block in the synthesis of various drugs due to its chemical structure that includes both amine and alcohol groups, which are common in many bioactive molecules.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-(benzylamino)-1-(thien-2-yl)ethanol is used as a starting material or intermediate in the development of new pharmaceutical agents, given its unique combination of functional groups and aromatic properties.

Upstream product

• 62019-66-3 α-(aminomethyl)-2-thiophenmethanol 
• 100-52-7 benzaldehyde 
• 66256-03-9 2-thiophen-2-yl-oxirane 
• 100-46-9 benzylamine 
• 313276-47-0 2-amminometil-2-tienilchetone 
• 98-03-3 thiophene-2-carbaldehyde 

Downstream Products

• 76175-43-4 6-(2-tienil)-4-benzilmorfolin-3-one 

Relevant academic research and scientific papers

The uncatalyzed ring opening of hetaryloxides with nitrogen nucleophiles. A dichotomy of regioselectivity

The uncatalyzed ring opening of the hetaryloxides 1, 2 and 3 with benzylamine and trimethylsilylazide has been studied being the observed regioselectivity different depending on the nucleophile used.

A simple two-step synthesis of 2-(alkylamino)-1-arylethanols, including racemic adrenaline, from aromatic aldehydes via 5-aryloxazolidines

Benzaldehydes react smoothly with nonstabilized azomethine ylides, generated in situ from sarcosine/formaldehyde or N-(methoxymethyl)-N- (trimethylsilylmethyl)benzylamine, to give 5-aryloxazolidines as intermediates. These were converted into 2-(alkylamino)-1-arylethanols in good yields by simple heating in methanol with hydrochloric acid, or by treatment with hydrazine hydrate in ethanol.

2-(2-Thienyl)morpholines with CNS activity

The synthesis and pharmacological investigation of 2-(2-thienyl)morpholine and some of its derivatives substituted on the nitrogen are described. The non-substituted compound showed interesting antidepressive properties with a pharmacological profile similar to that of imipramine.