76180-75-1Relevant academic research and scientific papers
Copper-Catalyzed Electrophilic Thiolation of Organozinc Halides by Using N-Thiophthalimides Leading to Polyfunctional Thioethers
Gra?l, Simon,Hamze, Clémence,Koller, Thadd?us J.,Knochel, Paul
, p. 3752 - 3755 (2019/02/13)
(Hetero)aryl, benzylic, and alkyl zinc halides were thiolated with N-thiophthalimides at 25 °C within 1 h in the presence of 5–10 % Cu(OAc)2?H2O to furnish the corresponding polyfunctionalized thioethers in good yields. This electrop
Palladium-Catalyzed Oxidative Cross-Coupling of Arylhydrazines and Arenethiols with Molecular Oxygen as the Sole Oxidant
Wang, Changliu,Zhang, Zhenming,Tu, Yongliang,Li, Ying,Wu, Jiale,Zhao, Junfeng
, p. 2389 - 2394 (2018/02/23)
A highly efficient palladium-catalyzed oxidative cross-coupling of arylhydrazines and arenethiols with molecular oxygen as the sole oxidant to afford unsymmetrical diaryl sulfides has been developed. The only byproducts are nitrogen and water. A broad range of functional groups, even the reactive iodides, are tolerated and thus offer the opportunity for further functionalization.
Copper(I)-catalyzed S-arylation of thiols with activated aryl chlorides on water
Herrero, María Teresa,SanMartin, Raul,Domínguez, Esther
experimental part, p. 1500 - 1503 (2009/05/07)
Copper chloride-catalyzed S-arylation of arenethiols is effected with activated aryl chlorides in neat water by using ethylenediamine as the pair ligand/base. This convenient, environmentally more friendly procedure for the coupling of aryl chlorides allows the arylation between sterically demanding coupling partners.
Isomerization-free sulfonylation and its application in the synthesis of PHA-565272A
Fleck, Thomas J.,Chen, Jiong Jack,Lu, Cuong V.,Hanson, Kari J.
, p. 334 - 338 (2012/12/22)
FeCl3 catalyzed an isomerization-free Friedel-Crafts sulfonylation between 1-naphthalenesulfonyl chloride and halobenzenes. The coupled halide was then displaced using 35% hydrazine in DMSO to provide the Fischer indole precursor. Pure 5-chloro-2-pentanone was the key for a successful Grandberg modification of Fischer indole synthesis that effectively constructed both the indole core and side chain of the target molecule. The development of these methods enabled a rapid preparation of kilogram quantities of PHA-565272A.
INHIBITORS OF AMYLOID BETA-PROTEIN PRODUCTION
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, (2008/06/13)
A method of protecting a warm-blooded mammal from the progression of Alzheimer"s disease, which comprises administering an effective amount of a compound of general formula.
CHEMICAL COMPOUNDS AS INHIBITORS OF AMYLOID BETA PROTEIN PRODUCTION
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, (2008/06/13)
A compound of the formula I in which Z is O or S; R11 is a halogen atom; R12 is a halogen atom or a trifluoromethyl group; and X is S, SO, SO2, O or NH; R4 is naphthyl, quinolinyl, benzimidazolyl, pyridyl, pyradazinyl, benzoxazolyl or benzothiazolyl, unsubstituted or substituted by one or two substituents selected from a halogen atom, (1-4C)alkyl, (1-4C)alkoxy, nitro, (1-4C)alkoxycarbonyl, halo(1-4C)alkyl, and phenyl; or a pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of amyloid beta-protein production.
