76180-77-3Relevant academic research and scientific papers
Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase
Yang, Ling-Ling,Xu, Wei,Yan, Jie,Su, Hui-Lin,Yuan, Chen,Li, Chao,Zhang, Xing,Yu, Zhu-Jun,Yan, Yu-Hang,Yu, Yamei,Chen, Qiang,Wang, Zhouyu,Li, Lin,Qian, Shan,Li, Guo-Bo
supporting information, p. 164 - 168 (2019/01/30)
A high-quality X-ray crystal structure reveals the mechanism of compound 1a inhibiting SIRT2 deacetylase and decanoylase. Structure-activity relationship (SAR) analysis of the synthesized derivatives of 1a reveals the high requirements needed for selectiv
CsOH·H2O-promoted synthesis of aryl sulfides via direct coupling of aryl halides and thiols
Varala, Ravi,Ramu,Mujahid Alam,Adapa, Srinivas R.
, p. 1614 - 1615 (2007/10/03)
We report here our observation that, using appropriate reaction conditions, CsOH·H2O-promoted coupling of aryl halides with thiols can be performed in moderate to good yields without a transition metal catalyst. Copyright
INHIBITORS OF AMYLOID BETA-PROTEIN PRODUCTION
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, (2008/06/13)
A method of protecting a warm-blooded mammal from the progression of Alzheimer"s disease, which comprises administering an effective amount of a compound of general formula.
CHEMICAL COMPOUNDS AS INHIBITORS OF AMYLOID BETA PROTEIN PRODUCTION
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, (2008/06/13)
A compound of the formula I in which Z is O or S; R11 is a halogen atom; R12 is a halogen atom or a trifluoromethyl group; and X is S, SO, SO2, O or NH; R4 is naphthyl, quinolinyl, benzimidazolyl, pyridyl, pyradazinyl, benzoxazolyl or benzothiazolyl, unsubstituted or substituted by one or two substituents selected from a halogen atom, (1-4C)alkyl, (1-4C)alkoxy, nitro, (1-4C)alkoxycarbonyl, halo(1-4C)alkyl, and phenyl; or a pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of amyloid beta-protein production.
