76182-89-3

Upstream product

• 1469-94-9 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione 
• 108-24-7 acetic anhydride 
• 4010-33-7 2-acetylphenyl benzoate 
• 118-93-4 o-hydroxyacetophenone 
• 98-88-4 benzoyl chloride 

Downstream Products

• 6880-06-4 3,3''-biflavone 

Relevant academic research and scientific papers

Synthesis and discovery of (I-3,II-3)-biacacetin as a novel non-zinc binding inhibitor of MMP-2 and MMP-9

Eleven biflavones (7a-b and 9a-i) were synthesised by a simple and efficient protocol and screened for MMP-2 and MMP-9 inhibitory activities. Amongst them, a natural product-like analog, (I-3,II-3)-biacacetin (9h) was found to be the most potent inhibitor

Synthesis of multi-functionalized chromeno[2, 3-c]pyrrol-9(2H)-ones: Investigation and application of Baker-Venkataraman rearrangement involved reactions catalyzed by 4-(Dimethylamino)pyridine

An efficient one-pot synthesis of multi-functionalized chromeno[2, 3-c]pyrrol-9(2H)-ones from 1, 3-diaryl-1, 3-diket-ones and amino acids is described. The synthesis is based on the 4-(dimethylamino)pyridine-catalyzed Baker-Venkatara-man rearrangement and

Studies in the chemistry of chromone epoxides

Chromones and isoflavones, but not flavones, were epoxidized by alkaline hydrogen peroxide. 3-Substituted chromone epoxides were considerably more stable than others; one isoflavone epoxide was converted into a fluorohydrin, another into a 1,2-diol. The latter is a 2-hydroxychromanone and a similarly structured compound was obtained by the cyclisation of 2'-benzoyloxy-2,2-dibromoacetophenone. Acid-catalysed ring-opening of chromone epoxides occurred regioselectively yielding 3-hydroxychromanones. Base-catalysed ring-opening also occurred regioselectively but at the 3-position. Acid- and base-catalysed hydrolysis of 2-methy-lisoflavone epoxide resulted in cleavage of both heterocyclic rings, yielding, respectively, a 1,3- and a 1,2-diketone. This epoxide formed a cyclic sulphate with sulphuric acid.