6880-06-4

Upstream product

• 1025-86-1 3-bromo-2-phenyl-chromen-4-one 
• 98153-12-9 3-iodo-2-phenyl-4H-1-benzopyran-4-one 
• 118-93-4 o-hydroxyacetophenone 
• 100-52-7 benzaldehyde 
• 76182-89-3 1-(2-acetoxyphenyl)-3-phenyl-1,3-propandione 
• 1469-94-9 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione 
• 4010-33-7 2-acetylphenyl benzoate 
• 98-88-4 benzoyl chloride 
• 1214-47-7 1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one 

Relevant academic research and scientific papers

Study on the synthesis of some new biflavonoids. VIII. A new synthesis of C3-linked biflavones, bithioflavones and bithiochromones

Reactions of the 3-iodo derivatives of flavones, thioflavones and thiochromones with finely divided copper at 200-210°C gave the title compounds respectively. Thus a new way to these compounds was provided.

Synthesis and discovery of (I-3,II-3)-biacacetin as a novel non-zinc binding inhibitor of MMP-2 and MMP-9

Eleven biflavones (7a-b and 9a-i) were synthesised by a simple and efficient protocol and screened for MMP-2 and MMP-9 inhibitory activities. Amongst them, a natural product-like analog, (I-3,II-3)-biacacetin (9h) was found to be the most potent inhibitor

Synthesis and antifungal activities of natural and synthetic biflavonoids

The synthesis of some natural and synthetic biflavonoids was performed in good overall yields starting from readily available materials via high yielding aldol and Ullmann condensations. Some of these compounds, especially bichalcones, display an interesting activity against fungi, higher than that of the corresponding monomers.