762-16-3Relevant articles and documents
An improved method for efficient and convenient synthesis of dioctanoyl peroxide
Yi, Guangshun,Sun, Baoquan,Li, Run,Chen, Depu,Zhou, Yuxiang,Cheng, Jing
, p. 759 - 762 (2002)
Octanoyl chloride in methylene dichloride was added to the hydrogen peroxide solution containing 5mol.1-1 NaOH in water-cooled flask, the reaction was carried out with high yields in ten or more minutes under vigorous stirring. The product was characterized by elemental analysis, molecular weight and spectral (IR, 1H NMR) analysis. Furthermore, the method proposed has the advantages of operation at room temperature with safety, reliability and short time consuming.
Unnatural α-Amino Acid Synthesized through α-Alkylation of Glycine Derivatives by Diacyl Peroxides
Tian, Hao,Xu, Wentao,Liu, Yuxiu,Wang, Qingmin
supporting information, p. 5005 - 5008 (2020/07/04)
We have developed a protocol for catalyst- and additive-free α-alkylation reactions of glycine derivatives with diacyl peroxides, which proceed by a pathway involving addition of alkyl radicals to imine intermediates. The diacyl peroxide substrate acts as both alkylation agent and oxidizing agent, which means it is atom-economical. It was applied to various glycine derivatives, dipeptides, and a 3,4-dihydroquinoxalin-2(1H)-one derivative and could be carried out on a gram scale, indicating its utility for late-stage functionalization.
Radical alkylation of C(sp3)-H bonds with diacyl peroxides under catalyst-free conditions
Tian, Hao,Xu, Wentao,Liu, Yuxiu,Wang, Qingmin
supporting information, p. 14813 - 14816 (2019/12/24)
Herein, we describe a protocol for alkylation reactions of C(sp3)-H bonds with diacyl peroxides by means of a process involving cross-coupling between an alkyl radical and an α-Aminoalkyl radical. The mild, catalyst-And additive-free conditions make this protocol superior to previously reported C(sp3)-H alkylation strategies. The protocol was applied to 1,2,3,4-Tetrahydroisoquinolines and a tetrahydro-β-carboline derivative and could be carried out on a gram scale, indicating its utility for the alkylation of late-stage synthetic intermediates.