762245-28-3Relevant academic research and scientific papers
FUSED HETEROCYCLIC BENZODIAZEPINE DERIVATIVES AND USES THEREOF
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, (2020/05/29)
The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.
NOVEL BENZODIAZEPINE DERIVATIVES AND USES THEREOF
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, (2019/12/24)
The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.
BENZODIAZEPINE DERIVATIVES
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, (2019/07/17)
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formulae (I), (II) and (III). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs)
Reid, Emily E.,Archer, Katie E.,Shizuka, Manami,McShea, Molly A.,Maloney, Erin K.,Ab, Olga,Lanieri, Leanne,Wilhelm, Alan,Ponte, Jose F.,Yoder, Nicholas C.,Chari, Ravi V.J.,Miller, Michael L.
, p. 2455 - 2458 (2019/07/30)
Antibody-drug conjugates (ADCs) incorporating potent indolinobenzodiazepine (IGN) DNA alkylators as the cytotoxic payload are currently undergoing clinical evaluation. The optimized design of these payloads consists of an unsymmetrical dimer possessing both an imine and an amine effectively eliminating DNA crosslinking and demonstrating improved tolerability in mice. Here we present an alternate approach to generating DNA alkylating ADCs by linking the IGN monomer with a biaryl system which has a high DNA binding affinity to potentially enhance tolerability. These BIA ADCs were found to be highly cytotoxic in vitro and demonstrated potent antitumor activity in vivo.
CYTOTOXIC BENZODIAZEPINE DERIVATIVES AND CONJUGATES THEREOF
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, (2018/11/22)
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formulae (I) and (II). The invention also provides conjugates of the benzodiazepine compounds linked to a
Synthesis of a novel tetrahydroisoquinolino[2,1-c][1,4]benzodiazepine ring system with DNA recognition potential
Kothakonda, Kiran Kumar,Bose, D. Subhas
, p. 4371 - 4373 (2007/10/03)
The first stereospecific synthesis of a novel tetrahydroisoquinolino[2,1-c] [1,4]benzodiazepine ring system with DNA recognition potential starting from (S)-1,2,3,4-tetrahydroisoquinoline carboxylic acid has been reported. We report the first stereospecif
