78183-55-8

Basic information

• Product Name: (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
• Synonyms: L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;METHYL (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLATE HYDROCHLORIDE;METHYL 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3(S)-CARBOXYLATE HYDROCHLORIDE;3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-, METHYL ESTER, HYDROCHLORIDE;(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;(S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;(S)-L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HCL
• CAS NO: 78183-55-8
• Molecular Formula: C₁₁H₁₃NO₂*ClH
• Molecular Weight: 227.69
• Mol File: 78183-55-8.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE(78183-55-8)
• EPA Substance Registry System: (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE(78183-55-8)

Safety Data

• Hazardous Substances Data: 78183-55-8(Hazardous Substances Data)

Usage

General Description

(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid methyl ester hydrochloride is a chemical compound with potential pharmaceutical applications. It is a derivative of tetrahydroisoquinoline, a bicyclic structure found in various natural products and synthetic compounds with diverse biological activities. The hydrochloride salt form of this compound is often used in medicinal chemistry research and drug development. Its pharmacological and biological properties may include analgesic, neuroprotective, and anti-inflammatory activities, making it an interesting target for potential drug discovery and development efforts. Further research is needed to fully understand the therapeutic potential and mechanisms of action of (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid methyl ester hydrochloride.

Upstream product

• 67-56-1 methanol 
• 77497-95-1 (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride 
• 74163-81-8 L-Tic-OH 
• 116174-78-8 benzyl (S)-1,2,3,4-tetrahydro-2-pivaloyl-isoquinoline-3-carboxylate 
• 77497-96-2 (S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, phenylmethylester 
• 63-91-2 L-phenylalanine 
• 116174-79-9 (3S)-1,2,3,4-tetrahydro-2-pivaloylisoquinoline-3-carboxylic acid 

Downstream Products

• 166169-81-9 (S)-1,2,3,4-tetrahydro-2-<3-methyl-N-<(phenylmethoxy)-carbonyl>-L-valyl>-3-isoquinolinecarboxylic acetic acid, methyl ester 
• 133211-48-0 (10aS)-2-ethyl-3-thioxo-1,2,3,5,10,10a-hexahydroimidazo[1,5-b]isoquinoline-1-one 
• 133211-48-0 2-ethyl-3-thioxo-1,2,3,5,10,10a-hexahydroimidazo[1,5-b]isoquinoline-1-one 
• 929207-35-2 methyl (3S)-N-[(1S)-1-methylbenzyl]carbamoyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 929207-36-3 methyl (3S)-N-cyclohexylcarbamoyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 929207-33-0 methyl (3S)-N-phenylcarbamoyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 133211-51-5 (10aS)-2-phenyl-3-thioxo-1,2,3,5,10,10a-hexahydroimidazo[1,5-b]isoquinoline-1-one 
• 133211-51-5 2-phenyl-3-thioxo-1,2,3,5,10,10a-hexahydroimidazo[1,5-b]isoquinoline-1-one 
• 762245-26-1 (S)-2-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester 
• 762245-28-3 (S)-2-(4-Benzyloxy-5-methoxy-2-nitro-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbaldehyde 
• 1054652-15-1 (S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid tert-butyl ester 
• 1027505-27-6 (S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid tert-butyl ester 

Relevant articles and documents

COMPOSITIONS AND METHODS RELATED TO MOLECULAR CONJUGATION

The invention relates to activated Michael acceptor (AMA) compounds that can undergo conjugation with biomolecules containing Michael donor moieties, thereby providing plasma-stable antibody-drug conjugates (ADCs). Pharmaceutical compositions of the ADCs are disclosed as well. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.

FUSED HETEROCYCLIC BENZODIAZEPINE DERIVATIVES AND USES THEREOF

The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS

Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.