762254-26-2Relevant academic research and scientific papers
Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitors
Quan, Mimi L.,Wong, Pancras C.,Wang, Cailan,Woerner, Francis,Smallheer, Joanne M.,Barbera, Frank A.,Bozarth, Jeffrey M.,Brown, Randi L.,Harpel, Mark R.,Luettgen, Joseph M.,Morin, Paul E.,Peterson, Tara,Ramamurthy, Vidhyashankar,Rendina, Alan R.,Rossi, Karen A.,Watson, Carol A.,Wei, Anzhi,Zhang, Ge,Seiffert, Dietmar,Wexler, Ruth R.
, p. 955 - 969 (2014/03/21)
Antithrombotic agents that are inhibitors of factor XIa (FXIa) have the potential to demonstrate robust efficacy with a low bleeding risk profile. Herein, we describe a series of tetrahydroquinoline (THQ) derivatives as FXIa inhibitors. Compound 1 was ide
Bicyclic heterocycles useful as serine protease inhibitors
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Page/Page column 22-23, (2010/02/14)
The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, L1, L2, X1, X2, X3, X4, X
TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS SERINE PROTEASE INHIBITORS
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Page 78, (2008/06/13)
The present invention provides compounds of Formula (I) ; or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, B, L1, L2, X1, X2, X3, X4, R4/su
Biarylmethyl indolines, indoles and tetrahydroquinolines, useful as serine protease inhibitors
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Page 28, (2010/02/09)
The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or hydrate form thereof, wherein the variables A, B, L1, L2, X1, X2, X3, X4 an
