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76227-98-0

1-(3-chlorophenyl)-azetidin-2-one is a chemical compound with the molecular formula C10H10ClNO. It is a derivative of azetidin-2-one, featuring a 3-chlorophenyl group attached to the nitrogen atom. 1-(3-chlorophenyl)-azetidin-2-one is known for its potential applications in the synthesis of pharmaceuticals and agrochemicals, particularly as a building block for the development of new drugs. Its structure provides a rigid cyclic framework that can be further functionalized, making it a valuable intermediate in organic chemistry. The presence of the chlorine atom on the phenyl ring also allows for additional chemical reactions, such as nucleophilic substitutions, which can be exploited in the creation of more complex molecules.

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  • 76227-98-0 Structure

  • Basic information

    1. Product Name: 1-(3-chlorophenyl)-azetidin-2-one
    2. Synonyms: 1-(3-chlorophenyl)-azetidin-2-one
    3. CAS NO:76227-98-0
    4. Molecular Formula:
    5. Molecular Weight: 181.622
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 76227-98-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(3-chlorophenyl)-azetidin-2-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(3-chlorophenyl)-azetidin-2-one(76227-98-0)
    11. EPA Substance Registry System: 1-(3-chlorophenyl)-azetidin-2-one(76227-98-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 76227-98-0(Hazardous Substances Data)

76227-98-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 76227-98-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,2,2 and 7 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 76227-98:
(7*7)+(6*6)+(5*2)+(4*2)+(3*7)+(2*9)+(1*8)=150
150 % 10 = 0
So 76227-98-0 is a valid CAS Registry Number.

76227-98-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3-chlorophenyl)-azetidin-2-one

1.2 Other means of identification

Product number -
Other names N-(3-chlorophenyl)azetidin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:76227-98-0 SDS

76227-98-0Relevant articles and documents

Modular Continuous Flow Synthesis of Imatinib and Analogues

Fu, Wai Chung,Jamison, Timothy F.

supporting information, p. 6112 - 6116 (2019/08/26)

A modular continuous flow synthesis of imatinib and analogues is reported. Structurally diverse imatinib analogues are rapidly generated using three readily available building blocks via a flow hydration/chemoselective C-N coupling sequence. The newly developed continuous flow hydration and amidation modules each exhibit a broad scope with good to excellent yields. Overall, the method described does not require solvent switches, in-line purifications, or packed-bed apparatuses due to the judicious manipulation of flow setups and solvent mixtures.

Synthesis of 2,3-dihydro-4(1H)-quinolones and the corresponding 4(1H)-quinolones via low-temperature fries rearrangement of N-arylazetidin-2- ones

Lange, Jens,Bissember, Alex C.,Banwell, Martin G.,Cade, Ian A.

experimental part, p. 454 - 470 (2011/10/09)

N-Arylazetidin-2-ones of the general form 1, which are readily prepared by GoldbergBuchwald-type copper-catalyzed coupling of N-unsubstituted azetidin-2-ones with the relevant aryl halide or using Mitsunobu cyclization processes, undergo smooth Fries-rearrangement in triflic acid at 018°C to give the isomeric 2,3-dihydro-4(1H)-quinolones (2). Dehydrogenation of the latter compounds using 10% Pd on C in 1.0M aqueous sodium hydroxide/propan-2-ol mixtures at ca. 82°C provides the corresponding 4(1H)-quinolones (3).

Formation of 2,3-Dihydro-4(1H)-quinolones and Related Compounds via Fries-type Acid-catalysed Rearrangement of 1-Arylazetidin-2-ones

Kano, Shinzo,Ebata, Tsutomu,Shibuya, Shiroshi

, p. 2105 - 2111 (2007/10/02)

A variety of 1-arylazetidin-2-ones were treated with trifluoroacetic acid under reflux, methanesulphonic acid at 100 deg C, or conc. sulphuric acid to give the corresponding 2,3-dihydro-4(1H)-quinolones via acyl migration and N-CO fission.In the case of 1-(3-substituted phenyl)azetidin-2-ones, two positional isomeric products, 5- and 7-substituted 2,3-dihydro-4(1H)-quinolones were obtained. 4-Methyl, 4-ethoxycarbonyl, and 4-piperidin-2-yl-1-arylazetidin-2-ones and their analogues were also converted into the corresponding 2-substituted 2,3-dihydro-4(1H)-quinolones under acidic conditions.The 3-substituted 1-phenylazetidin-2-ones (36) and (37) were converted into the furoquinoline systems (38) and (40), respectively, by application of this method.

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