76228-00-7

Upstream product

• 76227-97-9 3-(3-Benzyloxy-phenylamino)-propionic acid ethyl ester 
• 1484-26-0 3-(benzyloxy)aniline 
• 620597-98-0 N-(3-(benzyloxy)phenyl)-3-bromopropanamide 

Downstream Products

• 620598-00-7 7-benzyloxy-2,3-dihydro-1H-quinolin-4-one 
• 620597-74-2 7-(benzo[1,3]dioxol-5-yloxy)-3,4-dihydro-1-[4-(N-tert-butoxycarbonyl-N-benzylamino)butyl]-2H-quinoline-4-spiro-5'-1'-methyl-3'-[2-(1-tert-butoxycarbonyl-1H-indol-3-yl)-ethyl]-imidazolidine-2',4'-dione 
• 620597-71-9 7-(p-tolyloxy)-3,4-dihydro-1-[4-(N-tert-butoxycarbonyl-N-benzylamino)butyl]-2H-quinoline-4-spiro-5'-1'-methyl-3'-[2-(1-tert-butoxycarbonyl-1H-indol-3-yl)-ethyl]-imidazolidine-2',4'-dione 
• 620597-79-7 7-hydroxy-3,4-dihydro-1-[4-(N-tert-butoxycarbonyl-N-benzylamino)butyl]-2H-quinoline-4-spiro-5'-1'-methyl-3'-[2-(1-tert-butoxycarbonyl-1H-indol-3-yl)-ethyl]-imidazolidine-2',4'-dione 
• 620597-67-3 7-(p-tolyloxy)-3,4-dihydro-1-[4-(N-tert-butoxycarbonyl-N-benzylamino)butyl]-2H-quinoline-4-spiro-5'-1'-(1H-indol-3-ylmethyl)-3'-methyl-imidazolidine-2',4'-dione 
• 620597-75-3 7-(benzo[1,3]dioxol-5-yloxy)-3,4-dihydro-1-(4-benzylaminobutyl)-2H-quinoline-4-spiro-5'-1'-methyl-3'-[2-(1H-indol-3-yl)-ethyl]-imidazolidine-2',4'-dione 
• 620597-63-9 7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-[2-(1-tert-butoxycarbonylindol-3-yl)-ethyl]-1'-methyl-imidazolidine-2',4'-dione 
• 651322-95-1 7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-[2-(1-tert-butoxycarbonyl-1H-indol-3-yl)ethyl]-imidazolidine-2',4'-dione 
• 620597-72-0 7-(p-tolyloxy)-3,4-dihydro-1-(4-benzylaminobutyl)-2H-quinoline-4-spiro-5'-1'-methyl-3'-[2-(1H-indol-3-yl)-ethyl]-imidazolidine-2',4'-dione 
• 620598-08-5 7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-(1-tert-butoxycarbonyl-1H-indol-3-ylmethyl)-imidazolidine-2',4'-dione 
• 620597-68-4 7-(p-tolyloxy)-3,4-dihydro-1-(4-benzylaminobutyl)-2H-quinoline-4-spiro-5'-1'-(1H-indol-3-ylmethyl)-3'-methyl-imidazolidine-2',4'-dione 
• 651322-93-9 7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-(1-tert-butoxycarbonylindol-3-ylmethyl)-1'-methyl-imidazolidine-2',4'-dione 
• 651322-96-2 7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-1'-(1H-indol-3-ylmethyl)-3'-methyl-imidazolidine-2',4'-dione 
• 620597-66-2 7-(p-tolyloxy)-3,4-dihydro-2H-quinoline-4-spiro-5'-1'-(1H-indol-3-ylmethyl)-3'-methyl-imidazolidine-2',4'-dione 

Relevant academic research and scientific papers

Somatostatin analogue compounds

Compounds having somatostatin activity of the following Formula I, 1wherein, R1 is aryl, substituted-aryl, and aryl-(lower-alkyl)-; R2 is lower alkyl, amino substituted lower alkyl, -carboxy-(lower-alkyl), -carbamic acid-(lower-alkyl) and -carboxy-(lower-alkyl)-aryl; and R3 and R4 are independently, lower-alkyl, aryl, substituted-aryl, (substituted-aryl)-(lower-alkyl)-, heteroaryl, (heteroaryl)-(lower-alkyl)-, substituted-heteroaryl, (substituted heteroaryl)-(lower-alkyl)-, heterocyclic, heterocyclic-(lower-alkyl)-, substituted-heterocyclic, (substituted-heterocylic)-(lower alkyl)-, -carboxy-(lower-alkyl), and -carboxy-(lower-alkyl)-aryl; or a pharmaceutically acceptable, ester, ether, or salt thereof; methods for their use; and preparation.

Application of a novel design paradigm to generate general nonpeptide combinatorial scaffolds mimicking beta turns: Synthesis of ligands for somatostatin receptors

Nonpeptide compounds that mimic bioactive peptides are desirable for a number of clinical indications. We report a new practical method for the design of scaffolds exhibiting drug-like properties that are suitable for the display of peptide pharmacophores

Formation of 2,3-Dihydro-4(1H)-quinolones and Related Compounds via Fries-type Acid-catalysed Rearrangement of 1-Arylazetidin-2-ones

A variety of 1-arylazetidin-2-ones were treated with trifluoroacetic acid under reflux, methanesulphonic acid at 100 deg C, or conc. sulphuric acid to give the corresponding 2,3-dihydro-4(1H)-quinolones via acyl migration and N-CO fission.In the case of 1-(3-substituted phenyl)azetidin-2-ones, two positional isomeric products, 5- and 7-substituted 2,3-dihydro-4(1H)-quinolones were obtained. 4-Methyl, 4-ethoxycarbonyl, and 4-piperidin-2-yl-1-arylazetidin-2-ones and their analogues were also converted into the corresponding 2-substituted 2,3-dihydro-4(1H)-quinolones under acidic conditions.The 3-substituted 1-phenylazetidin-2-ones (36) and (37) were converted into the furoquinoline systems (38) and (40), respectively, by application of this method.