762288-82-4Relevant academic research and scientific papers
Protein surface-assisted enhancement in the binding affinity of an inhibitor for recombinant human carbonic anhydrase-II
Banerjee, Abir L.,Swanson, Michael,Roy, Bidhan C.,Jia, Xiao,Haldar, Manas K.,Mallik, Sanku,Srivastava
, p. 10875 - 10883 (2004)
We elaborate on a novel strategy for enhancing the binding affinity of an active-site directed inhibitor by attaching a tether group, designed to interact with the surface-exposed histidine residue(s) of enzymes. In this approach, we have utilized the rec
Two-prong inhibitors for human carbonic anhydrase II
Roy, Bidhan C.,Banerjee, Abir L.,Swanson, Michael,Jia, Xiao G.,Haldar, Manas K.,Mallik, Sanku,Srivastava
, p. 13206 - 13207 (2007/10/03)
The enzyme inhibitors are usually designed by taking into consideration the overall dimensions of the enzyme's active site pockets. This conventional approach often fails to produce desirable affinities of inhibitors for their cognate enzymes. To circumve
