7623-10-1Relevant articles and documents
Cu(I)-catalyzed oxidative cyclization of alkynyl oxiranes and oxetanes
Gronnier, Colombe,Kramer, Soren,Odabachian, Yann,Gagosz, Fabien
supporting information; experimental part, p. 828 - 831 (2012/03/07)
In the presence of a Cu(I) catalyst and a pyridine oxide, alkynyl oxiranes and oxetanes can be converted into functionalized five- or six-membered α,β-unsaturated lactones or dihydrofuranaldehydes. This new oxidative cyclization is proposed to proceed via an unusual allenyloxypyridinium intermediate.
Development of the conditions of synthesis of p-chlorophenyl methacrylate of the desired purity grade
Kobyakova,Kuz'Mina,Beshenova,Beloded
experimental part, p. 123 - 127 (2009/09/06)
The process of synthesis of p-chlorophenyl methacrylate by the reaction of p-chlorophenol with methacryloyl chloride was developed, identification and quantitative determination of admixtures in the targeted compound was carried out. The optimal conditions of the synthesis for obtaining the high quality monomer were developed.
An improved synthesis of captopril
Nam,Lee,Ryu
, p. 1843 - 1844 (2007/10/02)
An improved synthesis of captopril using methacrylic acid as the starting material is described. Treatment of methacrylic acid (I) with a hydrogen halide gave the 3-halogeno-2-methylpropanoic acids II and III, which were treated with thionyl chloride to yield the corresponding 3-halogeno-2-methylpropanoyl chlorides IV and V. Treatment of IV or V with L-proline yielded the N-(R,S-3-halogeno-2-methylpropanoyl)-L-prolines VI and VII, which were separated into optically pure R- and S-diastereoisomers using dicyclohexylamine. Treatment of halides of VI or VII with methanolic ammonium hydrosulfide gave captopril in 28% yield.
1,3-Diaryl-2-pyrazoline derivatives
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, (2008/06/13)
Disclosed are compounds of formula I, STR1 in which either R1, R2 and R3, which may be the same or different, each signifies a hydrogen atom, a chlorine or fluorine atom, an alkyl radical of 1 to 4 carbon atoms, an alkoxy radical of 1 to 4 carbon atoms, a cyano group, a group --SO3 M, an unsubstituted phenyl radical or a phenyl radical substituted by up to 2 substituents selected from chlorine, fluorine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms and the group --SO3 M, with the proviso that only one of R1, R2 and R3 signifies an unsubstituted or substituted phenyl radical Or two of R1 , R2 and R3, together, form a methylenedioxy group, the other of R1, R2 and R3 having one of the above significances, R4 signifies a hydrogen atom, a chlorine or fluorine atom, an alkyl radical of 1 to 4 carbon atoms or an alkoxy radical of 1 to 4 carbon atoms, R5 signifies a hydrogen atom, an alkyl radical of 1 to 4 carbon atoms, an unsubstituted phenyl radical or a phenyl radical substituted by 1 or 2 substituents selected from chlorine, fluorine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms and the group --SO3 M, R14 signifies an alkyl radical of 1 to 8 carbon atoms, A1 signifies a C1 to C3 alkylene chain, unsubstituted or substituted by up to two alkyl groups of 1 to 4 carbon atoms, Y signifies --O-- or --NR6 --, in which R6 signifies a hydrogen atom or an alkyl radical of 1 to 4 carbon atoms, Q signifies STR2 in which either R18 and R19, which may be the same or different, each signifies a hydrogen atom or an alkyl radical of 1 to 4 carbon atoms, or one of R18 or R19, together with R6, signifies an ethylene bridge, the other signifying a hydrogen atom or alkyl radical of 1 to 4 carbon atoms, Or Q signifies --SO3 M, or Q signifies --SR21 or --SR22≈ R23 An?, in which R21 signifies an alkyl radical of 1 to 4 carbon atoms, unsubstituted or substituted by a hydroxy radical or an alkoxy radical of 1 to 4 carbon atoms; or a phenyl or cycloalkyl radical of 5 to 7 carbon atoms, each unsubstituted or substituted by up to 2 substituents selected from chlorine, fluorine, C1-4 alkyl and C1-4 alkoxy, R22 and R23, which may be the same or different, each have a significance of R21, above, with the proviso that both do not simultaneously signify unsubstituted or substituted phenyl or cycloalkyl radicals, A2 signifies a C1 to C3 alkylene chain, unsubstituted or substituted by up to two alkyl groupsof 1 to 4 carbon atoms; or a phenylene group, unsubstituted or substituted by up to 2 substituents selected from chlorine, fluorine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms and the group --SO3 M, An≈ signifies a colorless organic or inorganic anion, and the M's, which may be the same or different, each signifies a hydrogen atom, or a non-chromophoric cation, which compounds, where Q signifies STR3 may be in quaternary ammonium salt form or in acid addition salt form, their production and use as optical brightening agents.
