76283-12-0

Basic information

• Product Name: 1-(bromomethyl)-4-chloro-2-methoxybenzene
• Synonyms: 1-(bromomethyl)-4-chloro-2-methoxybenzene
• CAS NO: 76283-12-0
• Molecular Formula: C₈H₈BrClO
• Molecular Weight: 235.51
• Mol File: 76283-12-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(bromomethyl)-4-chloro-2-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(bromomethyl)-4-chloro-2-methoxybenzene(76283-12-0)
• EPA Substance Registry System: 1-(bromomethyl)-4-chloro-2-methoxybenzene(76283-12-0)

Safety Data

• Hazardous Substances Data: 76283-12-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(bromomethyl)-4-chloro-2-methoxybenzene is used as a synthetic intermediate for the development of new pharmaceuticals. Its unique structure, including the bromomethyl, chloro, and methoxy groups, allows for the creation of a diverse range of medicinal compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(bromomethyl)-4-chloro-2-methoxybenzene is utilized as a building block for the synthesis of various agrochemicals, such as pesticides and herbicides. Its chemical properties make it suitable for the development of effective compounds to protect crops and enhance agricultural productivity.
Used in Dye Production:
1-(bromomethyl)-4-chloro-2-methoxybenzene is also employed in the production of dyes due to its aromatic structure and functional groups. Its versatility allows for the synthesis of a wide array of dye molecules with different color properties and applications in various industries, such as textiles and printing.
Used in Polymer Synthesis:
1-(bromomethyl)-4-chloro-2-methoxybenzene is used as a monomer or a building block in the synthesis of polymers. The presence of the bromomethyl, chloro, and methoxy groups in 1-(bromomethyl)-4-chloro-2-methoxybenzene enables the creation of polymers with specific properties, such as enhanced stability, reactivity, or solubility, which can be tailored for various applications.
Used in Organic Chemistry:
1-(bromomethyl)-4-chloro-2-methoxybenzene is a valuable compound in organic chemistry, serving as a starting material for the synthesis of various organic molecules. Its unique structure allows for further functionalization and modification, leading to the development of new compounds with a broad spectrum of applications in research and industry.

Upstream product

• 78955-90-5 methyl 4-chloro-2-methoxybenzoate 
• 40794-04-5 1-chloro-3-methoxy-4-methylbenzene 
• 90296-27-8 (4-chloro-2-methoxy-phenyl)methanol 
• 57479-70-6 2-methoxy-4-chlorobenzoic acid 

Downstream Products

• 16470-10-3 (4-Chloro-2-methylphenyl)acetonitrile 
• 1192485-79-2 1-(4-chloro-2-methoxybenzyl)-1H-indole 
• 122488-78-2 6-Chloro-9-(4-chloro-2-methoxy-benzyl)-2-trifluoromethyl-9H-purine 

Relevant articles and documents

RORγ MODULATORS

The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists

The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (TH17) cell proliferation. As such, synthetic small-molecule repressors (inverse agonists) targeting RORγ have been extensively studied for their potential as therapeutic agents for various autoimmune diseases. Alternatively, enhancing TH17 cell proliferation through activation (agonism) of RORγ may boost an immune response, thereby offering a potentially new approach in cancer immunotherapy. Herein we describe the development of N-arylsulfonyl indolines as RORγ agonists. Structure–activity studies reveal a critical linker region in these molecules as the major determinant for agonism. Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) analysis of RORγ–ligand complexes help rationalize the observed results.

Synthesis and structure-activity relationships of N-aryl(indol-3-yl)glyoxamides as antitumor agents

The synthesis and study of the structure-activity relationships of cytotoxic compounds based on N-pyridinyl or N-aryl-2-(1-benzylindol-3-yl)glyoxamide skeleton, represented by the lead structures D-24241 and D-24851, are described. The presence of N-(pyridin-4-yl) moiety was crucial for activity and 2-[1-(4-chloro-3-nitrobenzyl)-1H-indol-3-yl]-2-oxo-N-(pyridin-4-yl)aceta mide (55), the most potent derivative, showed IC50 = 39 nM, 51 nM and 11 nM against HeLa/KB (human cervix carcinoma), L1210 (murine leukemia) and SKOV3 (human ovarian carcinoma) cell lines proliferation assay, respectively, as active as the lead compounds.

1-H-3-aryl-pyrrolidine-2, 4-dione derivatives as pest-control agents

The present invention relates to new 1-H-3-aryl-pyrrolidine-2,4-dione derivatives of the formula (I) in which A, B, G, X, Y and Z have the meanings given in the description, to processes for their preparation, and to intermediates therefor. The compounds

Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines

A series of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)purines was synthesized and tested for antirhinovirus activity. Most of the compounds were synthesized by alkylation of 6-chloro-2-(trifluoromethyl)-9H-purine with the appropriate benzyl halide followed by displacement of the chloro group with dimethylamine. Alternatively, 6-(dimethylamino)-2-(trifluoromethyl)purine was alkylated with the appropriate benzyl halide. Although several different aryl substituents provided compounds with IC50's = 0.03 μM against rhinovirus serotype 1B, no congener was significantly more active than the parent 2. Twenty-three compounds were tested against 18 other serotypes, but none exhibited a uniform profile of activity.