76285-74-0

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 3-[(4-chlorophenyl)methyl]-2,3-dihydro-
• CAS NO: 76285-74-0
• Molecular Formula: C16H13ClO2
• Molecular Weight: 272.731
• Mol File: 76285-74-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 3-[(4-chlorophenyl)methyl]-2,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 3-[(4-chlorophenyl)methyl]-2,3-dihydro-(76285-74-0)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 3-[(4-chlorophenyl)methyl]-2,3-dihydro-(76285-74-0)

Safety Data

• Hazardous Substances Data: 76285-74-0(Hazardous Substances Data)

Upstream product

• 61661-20-9 (E)-3-(4-chloro-benzylidene)-chroman-4-one 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 7170-38-9 3-phenoxypropanoic acid 
• 3055-86-5 3-phenoxypropionitrile 
• 108-95-2 phenol 
• 50-00-0 formaldehyd 
• 22105-07-3 3-(4-chlorophenyl)-1-(2-hydroxyphenyl)propan-1-one 
• 3033-96-3 4-chloro-2'-hydroxychalcone 
• 104-88-1 4-chlorobenzaldehyde 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 1166789-94-1 3-(4-chlorobenzyl)chroman 
• 76285-81-9 4--3-(p-chlorobenzyl)chroman 
• 76285-83-1 4--3-(p-chlorobenzyl)chroman 
• 76300-27-1 4-(p-acetoxyphenyl)-3-(p-chlorobenzyl)chroman 
• 76285-78-4 4-(p-hydroxyphenyl)-3-(p-chlorobenzyl)chroman 
• 76285-76-2 3-(p-chlorobenzyl)-4-chromanol 

Relevant articles and documents

Synthesis, anticancer, structural, and computational docking studies of 3-benzylchroman-4-one derivatives

A series of 3-Benzylchroman-4-ones were synthesized and screened for anticancer activity by MTT assay. The compounds were evaluated against two cancerous cell lines BT549 (human breast carcinoma), HeLa (human cervical carcinoma), and one noncancerous cell

Studies in Antifertility Agents: Part XXIX - synthesis of 4--3-benzylchromans

7-H/Methoxy-4-chromanones (1, 2), obtained by PPA cyclization of the respective β-aryloxypropionic acids, on treatment with araldehydes (3, 4) give the corresponding 3-arylidene-4-chromanones (5, 6).Catalytic hydrogenation of 5 and 6 over Pd-C (10percent) with one mole of hydrogen affords 3-benzyl-4-chromanones (7, 8), while hydrogenation of 6 yields 3-benzyl-7-methoxychroman (9).NaBH4 reduction of 7 and 8 gives the corresponding 4-chromanols (10, 11) as a mixture of 3,4-cis- and -trans-isomers, which are arylated as such with PhOH-AlCl3 to give 4-(p-hydroxyphenyl)chromans(12, 13) as the main products.Treatment of 12 and 13 with Ac2O-pyridine and with p-NO2C6H4COCl-pyridine yields the corresponding p-acetoxy (14, 15) and p-nitrobenzoyloxy (16, 17) derivatives.Alkylation of 12 and 13 with N-(β-chloroethyl)pyrrolidine hydrochloride furnishes the title compounds, 4--3-(p-chloro/H)benzyl-7-H/methoxy-chromans (18, 19).None of these compounds prevents pregnancy at 5 mg/kg dose in rats.