763105-95-9

Upstream product

• 763105-94-8 (2R,3R)-1-(tert-butyloxycarbonyl)-3-hydroxy-2-phenylpiperidine 
• 32247-96-4 3,5-bis(trifluoromethyl)benzyl bromide 
• 763105-92-6 (2R,3S)-3-benzyloxy-1-(4-methoxybenzyl)-2-phenylpiperidine 
• 763105-93-7 (2R,3S)-1-(tert-butyloxycarbonyl)-3-hydroxy-2-phenylpiperidine 
• 763105-88-0 (S)-3-benzyloxy-1-(4-methoxybenzyl)-2,6-piperidinedione 
• 405517-45-5 (-)-tert-butyl (R)-3-oxo-2-phenylpiperidine-1-carboxylate 
• 121440-87-7 (+)-(S,E)-N-benzyl-(1,3-diphenyl-2-propenyl)amine 
• 872726-29-9 But-3-enoic acid benzyl-((E)-(S)-1,3-diphenyl-allyl)-amide 
• 872726-30-2 (1R,2R,6S)-3-Benzyl-2-phenyl-7-oxa-3-aza-bicyclo[4.1.0]heptan-4-one 
• 872726-31-3 (2R,3S)-1-benzyl-2-phenylpiperidin-3-ol 
• 872726-28-8 (6S)-N-benzyl-6-phenyl-3,6-dihydropyridin-2-one 
• 562817-52-1 (S)-N-(4-methoxybenzyl)-tetrahydro-5-oxo-2-furancarboxamide 
• 562817-53-2 (3S)-1-(4-methoxybenzyl)-3-hydroxypiperidine-2,6-dione 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 148700-91-8 L 733061 

Relevant academic research and scientific papers

A concise and practical catalytic asymmetric synthesis of (-)-CP-99,994 and (-)-L-733,061

A concise and practical catalytic asymmetric synthesis of (-)-CP-99,994 and (-)-L-733,061 was achieved. Key features involve the Pd-catalyzed asymmetric allylic amination and the ring-closing metathesis as key steps.

A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones: Application to the asymmetric syntheses of neurokinin substance P receptor antagonist (-)-L-733,061 and (-)-deoxocassine

A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones based on the regio- and diastereoselective reductive alkylation of (S)-3- benzyloxyglutarimide 7 is described. This method opens an entrance to chiral nonracemic substituted 3-piperidinols.