148700-91-8

Upstream product

• 763105-95-9 (2R,3R)-1-(tert-butyloxycarbonyl)-2-phenyl-3-[(3,5-bis(trifluoromethyl)benzyl)oxy]piperidine 
• 763105-94-8 (2R,3R)-1-(tert-butyloxycarbonyl)-3-hydroxy-2-phenylpiperidine 
• 763105-88-0 (S)-3-benzyloxy-1-(4-methoxybenzyl)-2,6-piperidinedione 
• 1291083-48-1 (R)-(-)-tert-butyl 5-(tert-butyldimethylsilyloxy)-2-oxo-1-phenylpentylcarbamate 
• 1291083-49-2 tert-butyl (1R,2R)-5-(tert-butyldimethylsilyloxy)-2-hydroxy-1-phenylpentylcarbamate 
• 1291083-50-5 tert-butyl (1R,2R)-2-(3,5-bis(trifluoromethyl)benzyloxy)-5-(tert-butyldimethylsilyloxy)-1-phenylpentylcarbamate 
• 1313494-66-4 C₂₅H₂₉F₆NO₄ 
• 271600-36-3 N-[phenyl(toluene-4-sulfonyl)methyl]tert-butoxycarboxyamide 
• 777944-33-9 N-(1E)-[(2R)-3-{[3,5-bis(trifluoromethyl)benzyl]oxy}-2-phenyl-2H-pyridin-1-yl]-N-[(S)-2-(1-methoxy-3-methylbutyl)]-benzamidine 
• 207509-50-0 3-{[3,5-bis(trifluoromethyl)benzyl]oxy}pyridine 
• 32247-96-4 3,5-bis(trifluoromethyl)benzyl bromide 
• 109-00-2 3-HYDROXYPYRIDINE 
• 562817-52-1 (S)-N-(4-methoxybenzyl)-tetrahydro-5-oxo-2-furancarboxamide 
• 562817-53-2 (3S)-1-(4-methoxybenzyl)-3-hydroxypiperidine-2,6-dione 

Relevant academic research and scientific papers

A concise enantioselective synthesis of L-(-)-733,061 and (2S,3S)-methyl 3-aminopiperidine-2-carboxylate using catalytic enantioselective aza-Henry reaction as key step

An efficient enantioselective synthesis of L-(-)-733,061 and (2S,3S)-methyl 3-aminopiperidine-2-carboxylate is accomplished by means of catalytic enantioselective aza-Henry reaction. A key feature of this protocol is organocatalysis as genesis of chiralit

A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones: Application to the asymmetric syntheses of neurokinin substance P receptor antagonist (-)-L-733,061 and (-)-deoxocassine

A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones based on the regio- and diastereoselective reductive alkylation of (S)-3- benzyloxyglutarimide 7 is described. This method opens an entrance to chiral nonracemic substituted 3-piperidinols.

Nucleophilic addition to 3-substituted pyridinium salts: Expedient syntheses of (-)-L-733,061 and (-)-CP-99,994

(Chemical Equation Presented) The addition of nucleophiles to 3-substituted pyridinium salts prepared from N-methylbenzamide and various pyridines has been investigated. Good to excellent regioselectivities favoring the 2,3-disubstituted 1,2-dihydropyridines were observed. The resulting 1,2-dihydropyridines led to the corresponding 2,3-disubstituted pyridines upon treatment with Mn(OAc)3/NaIO4. This methodology was also successfully applied to the enantioselective syntheses of (-)-L-733,061 and (-)-CP-99,994, two members of a new class of highly potent, nonpeptide, Substance P antagonists.