872726-31-3

Upstream product

• 1147426-75-2 (1S,2R)-(1-benzylpyrrolidin-2-yl)phenylmethanol 
• 121440-87-7 (+)-(S,E)-N-benzyl-(1,3-diphenyl-2-propenyl)amine 
• 872726-29-9 But-3-enoic acid benzyl-((E)-(S)-1,3-diphenyl-allyl)-amide 
• 872726-28-8 (6S)-N-benzyl-6-phenyl-3,6-dihydropyridin-2-one 
• 872726-30-2 (1R,2R,6S)-3-Benzyl-2-phenyl-7-oxa-3-aza-bicyclo[4.1.0]heptan-4-one 

Downstream Products

• 763105-93-7 (2R,3S)-1-(tert-butyloxycarbonyl)-3-hydroxy-2-phenylpiperidine 
• 405517-45-5 (-)-tert-butyl (R)-3-oxo-2-phenylpiperidine-1-carboxylate 
• 148687-76-7 (2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidine hydrochloride 
• 872726-33-5 CP 99994 dihydrochloride 
• 763105-95-9 (2R,3R)-1-(tert-butyloxycarbonyl)-2-phenyl-3-[(3,5-bis(trifluoromethyl)benzyl)oxy]piperidine 
• 872726-32-4 (2R,3R)-3-(2-Methoxy-benzylamino)-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 763105-94-8 (2R,3R)-1-(tert-butyloxycarbonyl)-3-hydroxy-2-phenylpiperidine 

Relevant academic research and scientific papers

Catalytic asymmetric synthesis of piperidines from pyrrolidine: Concisesynthesis of L-733,060

Catalytic asymmetric deprotonation-aldehyde trapping-ring expansion from a 5- to a 6-ring delivers a concise route to each stereoisomer of -hydroxy piperidines starting from W-Boc pyrrolidine. The methodology is utilized in a 5-step catalytic asymmetric synthesis of the neorokinin-1 receptor antagonist, (+)-L-733,060.

A concise and practical catalytic asymmetric synthesis of (-)-CP-99,994 and (-)-L-733,061

A concise and practical catalytic asymmetric synthesis of (-)-CP-99,994 and (-)-L-733,061 was achieved. Key features involve the Pd-catalyzed asymmetric allylic amination and the ring-closing metathesis as key steps.