76315-61-2Relevant academic research and scientific papers
One-pot synthesis of unsymmetrical N-heterocyclic carbene ligands from N-(2-iodoethyl)arylamine salts
Bhanu Prasad,Gilbertson, Scott R.
supporting information; experimental part, p. 3710 - 3713 (2011/02/28)
Image Presented An approach that provides symmetrical, unsymmetrical, and asymmetric N-heterocyclic carbene (NHC) ligands is reported. Reaction of iodoethanol with aniline provides N-(2-iodoethyl)arylamine salts that are then converted to the corresponding iodide. Reaction with aliphatic or aromatic amines followed by triethyl orthoformate was used to provide 26 different NHC ligands.
CHK-1 INHIBITORS
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Page/Page column 102, (2010/02/11)
Disclosed are novel inhibitors of Chk-1 and methods of using the same for therapy.
New macrocyclic ligands. XIV: Synthesis and X-ray structures of potentially pentadentate ligands incorporating non-symmetrically arranged N4S-, N3OS-, N2O2S- and N2S2O-heteroatoms
Baldwin, Darren S.,Bowden, Bruce F.,Duckworth, Paul A.,Lindoy, Leonard F.,McCool, Brian J.,Meehan, George V.,Vasilescu, Ioana M.,Wild, S. Bruce
, p. 597 - 603 (2007/10/03)
The synthesis and characterization of new mixed-donor macrocyclic ligands incorporating nitrogen, sulfur and/or oxygen heteroatoms are described. The new 17- or 18-membered macrocyclic rings contain unsymmetrical arrangements of their heteroatoms in contr
