76322-41-3Relevant academic research and scientific papers
Piperazinyl CCR1 antagonists-optimization of human liver microsome stability
Brown, Matthew F.,Bahnck, Kevin B.,Blumberg, Laura C.,Brissette, William H.,Burrell, Sara A.,Driscoll, James P.,Fedeles, Flavia,Fisher, Michael B.,Foti, Robert S.,Gladue, Ronald P.,Guzman-Martinez, Aikomari,Hayward, Matthew M.,Lira, Paul D.,Lillie, Brett M.,Lu, Yi,Lundquist, Greg D.,McElroy, Eric B.,McGlynn, Molly A.,Paradis, Timothy J.,Poss, Christopher S.,Roache, James H.,Shavnya, Andrei,Shepard, Richard M.,Trevena, Kristen A.,Tylaska, Laurie A.
, p. 3109 - 3112 (2008/03/13)
The synthesis, biological activity, and pharmacokinetic profile of CCR1 antagonists are described.
PIPERIDINE DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1ALPHA BINDING TO ITS RECEPTOR CCR1
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Page 43, (2010/02/06)
A compound of the formula (I) wherein a, b, c R1, R2, R3, R4, R5, R6, R7, Q, W, Y, and Z are defined as above , useful as potent and selective inhibitors of MIP-1α (CCL3) binding to its receptor CCR1 found on inflammatory and immunomodulatory cells (preferably leukocytes and lymphocytes).
Methods of using piperazine derivatives
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, (2008/06/13)
The present invention relates to compounds of the formula I and the pharmaceutically acceptable forms thereof; wherein X, Y, a, b, c, d, R1, R2, R3, R4 and R5 are as defined herein. Moreover, the present invention is also directed at pharmaceutical compositions comprising a compound of the formula I and a pharmaceutically acceptable carrier. Furthermore, the present invention is directed at methods of using the herein described compounds and compositions for treating or preventing a disorder or condition that can be treated or prevented by antagonizing the CCR1 receptor in a mammal.
Novel sulfonic acid derivatives
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, (2008/06/13)
A compound of the formula or the pharmaceutically acceptable salt thereof; wherein X, Y, a, b, c, d, R1, R2, R3 and R5 are as defined above useful to treat inflammation and other immune disorders.
Oxidative nucleophilic substitution of hydrogen in nitroarenes by silyl enol ethers
Ma?kosza, Mieczys?aw,Surowiec, Marek
, p. 6261 - 6266 (2007/10/03)
Enolates generated by treatment of silyl ketene acetals and enol ethers with fluoride ion sources add to nitroarenes to produce σH adducts that oxidize either with KMnO4 to give substituted nitroarenes or with dimethyldioxirane to give substituted phenols. In the latter case the oxidation results in replacement of the nitro group with a hydroxy group. It was shown that high effectiveness of these reactions is not due to stabilization of the σH adducts via O-silylation but due to the nature of the accompanying cation.
