76323-08-5

Upstream product

• 98-88-4 benzoyl chloride 
• 490-78-8 2,5-Dihydroxyacetophenone 
• 699-83-2 2,6-dihydroxylacetophenone 

Downstream Products

• 89263-93-4 1-(6-benzoyloxy-2-hydroxyphenyl)-3-phenylpropane-1,3-dione 
• 76323-09-6 2,5-dihydroxydibenzyloxymethane 
• 107139-52-6 [2-(2,5-Bis-benzoyloxy-phenyl)-2-oxo-ethyl]-triphenyl-phosphonium; bromide 
• 107127-93-5 1-(2,5-Dihydroxy-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone 
• 107127-96-8 6-Hydroxy-2-(2-nitro-phenyl)-chromen-4-one 
• 35794-88-8 6‐hydroxy‐4′‐methoxyflavone 
• 22105-12-0 6-hydroxy-2-methyl-chromen-4-one 
• 6665-83-4 6-hydroxyflavone 

Relevant academic research and scientific papers

Synthesis of novel flavone acyl esters and correlation of log P value with antioxidant and antimicrobial activity

Three series of flavones namely 6-hydroxy flavone, 6-chloro-3-hydroxy flavone, 3,6-dihydroxy flavone were synthesized. They were further benzoylated with different aromatic acid chlorides in the presence of pyridine gave three of acyl esters series (SCF 1 to 8, SHF 1 to 8 and SDF 1 to 8). The yields of all the substituted flavones were found satisfactory. These compounds were purified, characterized by their spectral data. log P and pKa value. They were screened for in vitro radical (DPP?) scavenging activity, showed appreciable activity. 7 compounds showed antimicrobial activity against Gram-positive bacteria. Further, the MIC values of these 7 compounds were also determined. All the compounds showing antioxidant activity also showed antibacterial activity. The relationship between log P, antioxidant and antibacterial activity was established.

Structural Studies on Bio-active Compounds. Part 12. Tautomerism and Conformation of Aryl-substituted 1-(2-Hydroxyphenyl)-3-phenylpropane-1,3-diones in the Solid Phase and in Solution

The tautomerism of a series of aryl-substituted 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones has been studied in deuteriochloroform solution by 1H n.m.r. techniques and, in the case of 1-(2-hydroxy-4-methoxyphenyl)-3-phenylpropane-1,3-dione and 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylpropane-1,3-dione, in the solid state by X-ray crystallography.Of these compounds, most exist between 80 and 95percent in the enolised form in solution and 1-(2-hydroxy-4-methoxyphenyl)-3-phenylpropane-1,3-dione adopts this tautomer in the crystal.However, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylpropane-1,3-dione is present as the diketone in the solid phase and enolises very slowly in solution. 1-(6-Benzoyloxy-2-hydroxyphenyl)-3-hydroxy-3-phenylprop-2-en-1-one is shown by 1H n.m.r. spectroscopy possibly to adopt a 'coiled' conformation in solution in deuteriochloroform.